Monodisperse polyvinylpyrrolidone-coated CoFe2O4 nanoparticles: Synthesis, characterization and cytotoxicity study

被引：36

作者：

Wang, Guangshuo ^{[1
]}

Ma, Yingying ^{[1
]}

Mu, Jingbo ^{[1
]}

Zhang, Zhixiao ^{[1
]}

Zhang, Xiaoliang ^{[1
]}

Zhang, Lina ^{[1
]}

Che, Hongwei ^{[1
]}

Bai, Yongmei ^{[1
]}

Hou, Junxian ^{[1
]}

Xie, Hailong ^{[1
]}

机构：

[1] Hebei Univ Engn, Coll Equipment Mfg, Handan 056038, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2016年 / 365卷

基金：

中国国家自然科学基金;

关键词：

CoFe2O4; nanoparticles; Polyvinylpyrrolidone-coated; Monodisperse; Sonochemical method; Superparamagnet ism; Low cytotoxicity; COBALT FERRITE NANOPARTICLES; MAGNETIC NANOPARTICLES; FUNCTIONALIZATION; COPRECIPITATION; PARTICLES; ACID;

D O I：

10.1016/j.apsusc.2016.01.031

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, monodisperse cobalt ferrite (CoFe2O4) nanoparticles were prepared successfully with various additions of polyvinylpyrrolidone (PVP) by sonochemical method, in which PVP served as a stabilizer and dispersant. The effects and roles of PVP on the morphology, microstructure and magnetic properties of the obtained CoFe2O4 were investigated in detail by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and superconducting quantum interference device (SQUID). It was found that PVP-coated behavior showed relatively well dispersion with narrow size distribution. The field-dependent magnetization curves indicated superparamagnetic behavior of PVP-coated CoFe2O4 with moderate saturation magnetization and hydrophilic character at room temperature. More importantly, the in vitro cytotoxicity testing exhibited negligible cytotoxicity of as-prepared PVP-CoFe2O4 even at the concentration as high as 150 mu g/mL after 24 h treatment. Considering the superparamagnetic properties, hydrophilic character and negligible cytotoxicity, the monodisperse CoFe2O4 nanoparticles hold great potential in a variety of biomedical applications. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：114 / 119

页数：6

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