Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction

被引:139
作者
Leung, Victor Y. L.
Chan, Danny
Cheung, Kenneth M. C.
机构
[1] Univ Hong Kong, Med Ctr, Queen Mary Hosp, Dept Orthoped & Traumatol, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
关键词
mesenchymal stem cells; intervertebral disc degeneration; intervertebral disc regeneration; tissue engineering;
D O I
10.1007/s00586-006-0183-z
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect is suggested to be dependent on the severity of degeneration. Mesenchymal stem cells (MSCs) are able to escape alloantigen recognition which is an advantage for allogenic transplantation. A number of injectable scaffolds have been described and various methods to pre-modulate MSCs' activity have been tested. In future, work will need to address the use of mesenchymal stem cells in large animal models and the fate of the implanted mesenchymal stem cells, particularly in the long term, in animals. This review examines the state-of-the-art in the field of stem cell regeneration of the intervertebral disc, and critically discusses, with scientific support, the issues involved, before stem cells could be used in human subjects.
引用
收藏
页码:S406 / S413
页数:8
相关论文
共 92 条
[1]  
Adams Michael A, 2004, Acupunct Med, V22, P178
[2]   Genetic risk factors for lumbar disc disease [J].
Ala-Kokko, L .
ANNALS OF MEDICINE, 2002, 34 (01) :42-47
[3]   Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits [J].
An, HS ;
Takegami, K ;
Kamada, H ;
Nguyen, CM ;
Thonar, EJMA ;
Singh, K ;
Andersson, GB ;
Masuda, K .
SPINE, 2005, 30 (01) :25-31
[4]  
Anderson D Greg, 2005, Spine J, V5, p297S, DOI 10.1016/j.spinee.2005.02.019
[5]   An allele of COL9A2 associated with intervertebral disc disease [J].
Annunen, S ;
Paassilta, P ;
Lohiniva, J ;
Perälä, M ;
Pihlajamaa, T ;
Karppinen, J ;
Tervonen, O ;
Kröger, H ;
Lähde, S ;
Vanharanta, H ;
Ryhänen, L ;
Göring, HHH ;
Ott, J ;
Prockop, DJ ;
Ala-Kokko, L .
SCIENCE, 1999, 285 (5426) :409-412
[6]   Matrix-assisted cell transfer for intervertebral disc cell therapy [J].
Bertram, H ;
Kroeber, M ;
Wang, H ;
Unglaub, F ;
Guehring, T ;
Carstens, C ;
Richter, W .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 331 (04) :1185-1192
[7]   Synchronous lumbar disc herniation in adult twins. Case report [J].
Bhardwaj, R ;
Midha, R .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2004, 31 (04) :554-557
[8]   Cell viability in scoliotic discs in relation to disc deformity and nutrient levels [J].
Bibby, SRS ;
Fairbank, JCT ;
Urban, MR ;
Urban, JPG .
SPINE, 2002, 27 (20) :2220-2227
[9]   Classification of age-related changes in lumbar intervertebral discs [J].
Boos, N ;
Weissbach, S ;
Rohrbach, H ;
Weiler, C ;
Spratt, KF ;
Nerlich, AG .
SPINE, 2002, 27 (23) :2631-2644
[10]   Imaging transgenic animals [J].
Budinger, TF ;
Benaron, DA ;
Koretsky, AP .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 1999, 1 :611-648