Programmed cell death as a defence against infection

被引:793
作者
Jorgensen, Ine [1 ]
Rayamajhi, Manira [2 ]
Miao, Edward A. [3 ,4 ]
机构
[1] Natl Hosp Norway, Oslo Univ Hosp, Dept Immunol, Sognsvannsveien 20, N-0372 Oslo, Norway
[2] Camargo Pharmaceut Serv, 2505 Meridian Pkwy,Suite 175, Durham, NC 27713 USA
[3] Univ N Carolina, Dept Microbiol & Immunol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27599 USA
基金
美国国家卫生研究院;
关键词
NEUTROPHIL EXTRACELLULAR TRAPS; NLRP3 INFLAMMASOME ACTIVATION; NF-KAPPA-B; INFLUENZA-A VIRUS; III SECRETION APPARATUS; MIXED LINEAGE KINASE; GASDERMIN-D; STREPTOCOCCUS-PNEUMONIAE; LISTERIA-MONOCYTOGENES; NLRC4; INFLAMMASOME;
D O I
10.1038/nri.2016.147
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and viral infection: apoptosis, necroptosis, pyroptosis and NETosis. We describe the interactions that interweave different programmed cell death pathways, which create complex signalling networks that cross-guard each other in the evolutionary 'arms race' with pathogens. Finally, we describe how the resulting cell corpses-apoptotic bodies, pore-induced intracellular traps (PITs) and neutrophil extracellular traps (NETs)-promote the clearance of infection.
引用
收藏
页码:151 / 164
页数:14
相关论文
共 179 条
[1]   Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium [J].
Aachoui, Youssef ;
Kajiwara, Yuji ;
Leaf, Irina A. ;
Mao, Dat ;
Ting, Jenny P. -Y. ;
Coers, Joern ;
Aderem, Alan ;
Buxbaum, Joseph D. ;
Miao, Edward A. .
CELL HOST & MICROBE, 2015, 18 (03) :320-332
[2]   Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection [J].
Aachoui, Youssef ;
Sagulenko, Vitaliya ;
Miao, Edward A. ;
Stacey, Katryn J. .
CURRENT OPINION IN MICROBIOLOGY, 2013, 16 (03) :319-326
[3]   Caspase-11 Protects Against Bacteria That Escape the Vacuole [J].
Aachoui, Youssef ;
Leaf, Irina A. ;
Hagar, Jon A. ;
Fontana, Mary F. ;
Campos, Cristine G. ;
Zak, Daniel E. ;
Tan, Michael H. ;
Cotter, Peggy A. ;
Vance, Russell E. ;
Aderem, Alan ;
Miao, Edward A. .
SCIENCE, 2013, 339 (6122) :975-978
[4]   Inflammatory Stimuli Regulate Caspase Substrate Profiles [J].
Agard, Nicholas J. ;
Maltby, David ;
Wells, James A. .
MOLECULAR & CELLULAR PROTEOMICS, 2010, 9 (05) :880-893
[5]   GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [J].
Aglietti, Robin A. ;
Estevez, Alberto ;
Gupta, Aaron ;
Ramirez, Monica Gonzalez ;
Liu, Peter S. ;
Kayagaki, Nobuhiko ;
Ciferri, Claudio ;
Dixit, Vishva M. ;
Dueber, Erin C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7858-7863
[6]   Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming [J].
Allam, Ramanjaneyulu ;
Lawlor, Kate E. ;
Yu, Eric Chi-Wang ;
Mildenhall, Alison L. ;
Moujalled, Donia M. ;
Lewis, Rowena S. ;
Ke, Francine ;
Mason, Kylie D. ;
White, Michael J. ;
Stacey, Katryn J. ;
Strasser, Andreas ;
O'Reilly, Lorraine A. ;
Alexander, Warren ;
Kile, Benjamin T. ;
Vaux, David L. ;
Vince, James E. .
EMBO REPORTS, 2014, 15 (09) :982-990
[7]   Viral apoptotic mimicry [J].
Amara, Ali ;
Mercer, Jason .
NATURE REVIEWS MICROBIOLOGY, 2015, 13 (08) :461-469
[8]   Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling [J].
Antonopoulos, Christina ;
Russo, Hana M. ;
El Sanadi, Caroline ;
Martin, Bradley N. ;
Li, Xiaoxia ;
Kaiser, William J. ;
Mocarski, Edward S. ;
Dubyak, George R. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (33) :20167-20184
[9]   Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy? [J].
Behar, Samuel M. ;
Divangahi, Maziar ;
Remold, Heinz G. .
NATURE REVIEWS MICROBIOLOGY, 2010, 8 (09) :668-674
[10]   An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps [J].
Beiter, K ;
Wartha, F ;
Albiger, B ;
Normark, S ;
Zychlinsky, A ;
Henriques-Normark, B .
CURRENT BIOLOGY, 2006, 16 (04) :401-407