Multiple Sclerosis and Autoimmunity: A Veiled Relationship

被引：28

作者：

Barkhane, Zineb ^{[1
]}

Elmadi, Jalal ^{[2
]}

Kumar, Lakshmi Satish ^{[3
]}

Pugalenthi, Lakshmi Sree ^{[4
]}

Ahmad, Mahlika ^{[5
]}

Reddy, Sanjana ^{[6
]}

机构：

[1] Univ Hassan 2, Res, Fac Med & Pharm Casablanca, Casablanca, Morocco

[2] Univ Nacl Autonoma Honduras, Fac Ciencias Med, Tegucigalpa, Honduras

[3] Univ Perpetual Help Syst, Daisy Antonio Laperal Tamayo DALTA, Internal Med, Manila, Philippines

[4] Bicol Christian Coll Med, Internal Med, Legazpi, Philippines

[5] Ziauddin Univ, Res, Karachi, Pakistan

[6] Bogomolets Natl Med Univ, Med, Kiev, Ukraine

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 04期

关键词：

common etiology; autoimmunity; demyelinating disease; autoimmune diseases; multiple sclerosis; SHARED EPITOPE HYPOTHESIS; TYPE-1; DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION; GUILLAIN-BARRE-SYNDROME; RHEUMATOID-ARTHRITIS; VITAMIN-D; HELICOBACTER-PYLORI; MYASTHENIA-GRAVIS; DISEASE-ACTIVITY; EARLY-CHILDHOOD;

D O I：

10.7759/cureus.24294

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple sclerosis (MS) is an autoimmune inflammatory illness that affects the central nervous system (CNS) when the body's immune system attacks its tissue. It is characterized by demyelination and varying degrees of axonal loss. This article has compiled various studies elaborating MS and other autoimmune diseases (ADs) co-occurrence. Several conditions that fall into this category, including type 1 diabetes (T1D), rheumatoid arthritis (RA), Guillain-Barre syndrome (GBS), myasthenia gravis (MG), and many others, are found in MS patients and their relatives, suggesting one or more common etiologic mechanisms, including genetic, environmental, and immunological factors, supporting the concept of a possible influence of poly-autoimmunity on MS and the rest of ADs, as well as providing a significant feature for early detection of the disease and also a potential treatment option by clinical neurologists.

引用

页数：12

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