Target-Based Drug Discovery: the Emerging Success of Frontal Affinity Chromatography Coupled to Mass Spectrometry

被引：33
|
作者：
Calleri, Enrica [1 ]
Temporini, Caterina [1 ]
Caccialanza, Gabriele [1 ]
Massolini, Gabriella [1 ]
机构：
[1] Univ Pavia, Dipartimento Chim Farmaceut, I-27100 Pavia, Italy
来源：
CHEMMEDCHEM | 2009年 / 4卷 / 06期
关键词：
drug discovery; high-throughput screening; binding assays; mass spectrometry; FAC-MS; IMMOBILIZED P-GLYCOPROTEIN; RECEPTOR STATIONARY-PHASE; SMALL-MOLECULE INHIBITORS; TYROSINE KINASE RECEPTOR; LIQUID-CHROMATOGRAPHY; MS DETECTION; SCREENING TECHNIQUES; BINDING AFFINITIES; LEAD GENERATION; FAC-MS;
D O I：
10.1002/cmdc.200800436
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：905 / 916
页数：12
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