Ibrutinib provides favourable survival outcomes in patients with comorbidities versus established therapies

被引:9
作者
Burger, Jan A. [1 ]
Cramer, Paula [2 ]
Barr, Paul M. [3 ]
Dilhuydy, Marie-Sarah [4 ]
Mato, Anthony [5 ]
Byrd, John C. [6 ]
Chang, Stephen [7 ]
Graef, Thorsten [7 ]
Lin, Tony [7 ]
Tedeschi, Alessandra [8 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[2] Univ Cologne, German CLL Study Grp, Cologne, Germany
[3] Univ Rochester, Canc Ctr, Rochester, NY USA
[4] Ctr Hosp Univ Bordeaux, Bordeaux, France
[5] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[6] Ohio State Univ, Columbus, OH 43210 USA
[7] Pharmacyclics LLC, Sunnyvale, CA USA
[8] Azienda Osped Niguarda Ca Granda, Milan, Italy
关键词
ibrutinib; Bruton's tyrosine kinase inhibitor; chronic lymphocytic leukaemia; survival outcomes; comorbidities; CHRONIC LYMPHOCYTIC-LEUKEMIA;
D O I
10.1111/bjh.15784
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:175 / 180
页数:6
相关论文
共 8 条
[1]   Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model [J].
Baumann, Tycho ;
Delgado, Julio ;
Santacruz, Rodrigo ;
Martinez-Trillos, Alejandra ;
Royo, Cristina ;
Navarro, Alba ;
Pinyol, Magda ;
Rozman, Mara ;
Pereira, Arturo ;
Villamor, Neus ;
Aymerich, Marta ;
Lopez, Cristina ;
Carrio, Anna ;
Montserrat, Emili .
HAEMATOLOGICA, 2014, 99 (10) :1599-1604
[2]   Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia [J].
Burger, J. A. ;
Tedeschi, A. ;
Barr, P. M. ;
Robak, T. ;
Owen, C. ;
Ghia, P. ;
Bairey, O. ;
Hillmen, P. ;
Bartlett, N. L. ;
Li, J. ;
Simpson, D. ;
Grosicki, S. ;
Devereux, S. ;
McCarthy, H. ;
Coutre, S. ;
Quach, H. ;
Gaidano, G. ;
Maslyak, Z. ;
Stevens, D. A. ;
Janssens, A. ;
Offner, F. ;
Mayer, J. ;
O'Dwyer, M. ;
Hellmann, A. ;
Schuh, A. ;
Siddiqi, T. ;
Polliack, A. ;
Tam, C. S. ;
Suri, D. ;
Cheng, M. ;
Clow, F. ;
Styles, L. ;
James, D. F. ;
Kipps, T. J. ;
Keating, Michael ;
Jen, Jie ;
Jindra, Pavel ;
Simkovic, Martin ;
Braester, Andrei ;
Ruchlemer, Rosa ;
Foa, Roberto ;
Semenzato, Gianpietro ;
Hawkins, Timothy ;
Atanasio, Carolina Moreno ;
Demirkan, Fatih ;
Kaynar, Leylagul ;
Pylypenko, Halyna ;
Fox, Christopher ;
Thirman, Michael ;
Campbell, Philip .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (25) :2425-2437
[3]  
Busch R., 2014, BLOOD, V124, P19, DOI [10.1182/blood.V124.21.19.19, DOI 10.1182/BLOOD.V124.21.19.19]
[4]   Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia [J].
Byrd, J. C. ;
Brown, J. R. ;
O'Brien, S. ;
Barrientos, J. C. ;
Kay, N. E. ;
Reddy, N. M. ;
Coutre, S. ;
Tam, C. S. ;
Mulligan, S. P. ;
Jaeger, U. ;
Devereux, S. ;
Barr, P. M. ;
Furman, R. R. ;
Kipps, T. J. ;
Cymbalista, F. ;
Pocock, C. ;
Thornton, P. ;
Caligaris-Cappio, F. ;
Robak, T. ;
Delgado, J. ;
Schuster, S. J. ;
Montillo, M. ;
Schuh, A. ;
de Vos, S. ;
Gill, D. ;
Bloor, A. ;
Dearden, C. ;
Moreno, C. ;
Jones, J. J. ;
Chu, A. D. ;
Fardis, M. ;
McGreivy, J. ;
Clow, F. ;
James, D. F. ;
Hillmen, P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (03) :213-223
[5]   Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study [J].
Chanan-Khan, Asher ;
Cramer, Paula ;
Demirkan, Fatih ;
Fraser, Graeme ;
Silva, Rodrigo Santucci ;
Grosicki, Sebastian ;
Pristupa, Aleksander ;
Janssens, Ann ;
Mayer, Jiri ;
Bartlett, Nancy L. ;
Dilhuydy, Marie-Sarah ;
Pylypenko, Halyna ;
Loscertales, Javier ;
Avigdor, Abraham ;
Rule, Simon ;
Villa, Diego ;
Samoilova, Olga ;
Panagiotidis, Panagiots ;
Goy, Andre ;
Mato, Anthony ;
Pavlovsky, Miguel A. ;
Karlsson, Claes ;
Mahler, Michelle ;
Salman, Mariya ;
Sun, Steven ;
Phelps, Charles ;
Balasubramanian, Sriram ;
Howes, Angela ;
Hallek, Michael ;
Assouline, S. ;
Bence-Bruckler, I. ;
Buckstein, R. ;
Fraser, G. ;
Larratt, L. ;
Minuk, L. ;
Villa, D. ;
Angevine, A. ;
Bartlett, N. ;
Bixby, D. ;
Caimi, P. ;
Chanan-Khan, A. ;
Craig, M. ;
Forero-Torres, A. ;
Ganguly, S. ;
Goy, A. ;
Heffner, L. ;
Hermann, R. ;
Lansigan, F. ;
Leis, J. ;
Letzer, J. .
LANCET ONCOLOGY, 2016, 17 (02) :200-211
[6]   Interactions between comorbidity and treatment of chronic lymphocytic leukemia: results of German Chronic Lymphocytic Leukemia Study Group trials [J].
Goede, Valentin ;
Cramer, Paula ;
Busch, Raymonde ;
Bergmann, Manuela ;
Stauch, Martina ;
Hopfinger, Georg ;
Stilgenbauer, Stephan ;
Doehner, Hartmut ;
Westermann, Anne ;
Wendtner, Clemens M. ;
Eichhorst, Barbara ;
Hallek, Michael .
HAEMATOLOGICA, 2014, 99 (06) :1095-1100
[7]   Comorbidities Predict Inferior Outcomes in Chronic Lymphocytic Leukemia Treated With Ibrutinib [J].
Gordon, Max J. ;
Churnetski, Michael ;
Alqahtani, Hamood ;
Rivera, Xavier ;
Kittai, Adam ;
Amrock, Stephen M. ;
James, Spencer ;
Hoff, Sheila ;
Manda, Sudhir ;
Spurgeon, Stephen E. ;
Choi, Michael ;
Cohen, Jonathon B. ;
Persky, Daniel ;
Danilov, Alexey V. .
CANCER, 2018, 124 (15) :3192-3200
[8]   Prevalence of Acid-Reducing Agents (ARA) in Cancer Populations and ARA Drug-Drug Interaction Potential for Molecular Targeted Agents in Clinical Development [J].
Smelick, Gillian S. ;
Heffron, Timothy P. ;
Chu, Laura ;
Dean, Brian ;
West, David A. ;
DuVall, Scott L. ;
Lum, Bert L. ;
Budha, Nageshwar ;
Holden, Scott N. ;
Benet, Leslie Z. ;
Frymoyer, Adam ;
Dresser, Mark J. ;
Waret, Joseph A. .
MOLECULAR PHARMACEUTICS, 2013, 10 (11) :4055-4062