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Copper-mediated C-H(sp2)/C-H(sp3) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to an isoquinolinone scaffold
被引:52
作者:
Zhu, Wei
[1
]
Zhang, Dengyou
[1
]
Yang, Nan
[1
]
Liu, Hong
[1
]
机构:
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China
基金:
中国国家自然科学基金;
关键词:
C-H BONDS;
DIRECT FUNCTIONALIZATION;
DIRECTING GROUP;
ACTIVATION;
ARYL;
ARYLATION;
ARENE;
ALKALOIDS;
HALIDES;
D O I:
10.1039/c4cc03837a
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
A facile, copper-mediated, direct C-H(sp(2))/C-H(sp(3)) bond coupling of benzoic acid derivatives with ethyl cyanoacetate by the deployment of an 8-aminoquinoline moiety as a bidentate directing group is disclosed. Such a unique transformation provides a new strategy for the construction of an isoquinolinone scaffold as one of the privileged cores.
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页码:10634 / 10636
页数:3
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