Copper-mediated C-H(sp2)/C-H(sp3) coupling of benzoic acid derivatives with ethyl cyanoacetate: an expedient route to an isoquinolinone scaffold

被引：52

作者：

Zhu, Wei ^{[1
]}

Zhang, Dengyou ^{[1
]}

Yang, Nan ^{[1
]}

Liu, Hong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 73期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; DIRECT FUNCTIONALIZATION; DIRECTING GROUP; ACTIVATION; ARYL; ARYLATION; ARENE; ALKALOIDS; HALIDES;

D O I：

10.1039/c4cc03837a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile, copper-mediated, direct C-H(sp(2))/C-H(sp(3)) bond coupling of benzoic acid derivatives with ethyl cyanoacetate by the deployment of an 8-aminoquinoline moiety as a bidentate directing group is disclosed. Such a unique transformation provides a new strategy for the construction of an isoquinolinone scaffold as one of the privileged cores.

引用

页码：10634 / 10636

页数：3

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