Personal neoantigen cancer vaccines The momentum builds

被引：46

作者：

Fritsch, Edward F. ^{[1
,2
]}

Hacohen, Nir ^{[1
,3
]}

Wu, Catherine J. ^{[1
,2
,4
]}

机构：

[1] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

[2] Dana Farber Canc Inst, Canc Vaccine Ctr, Dept Med Oncol, Boston, MA 02115 USA

[3] Massachusetts Gen Hosp, Dept Med, Div Allergy Immunol & Rheumatol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 06期

关键词：

neoantigen; vaccine; personalized; central tolerance; T cells; T-CELLS; PATIENT;

D O I：

10.4161/onci.29311

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient's tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer. Despite manufacturing complexity, outstanding questions and desired further improvements, neoantigen vaccines are currently undergoing clinical evaluation.

引用

页数：3

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