Ru3(CO)12-catalyzed C-H/CO/olefin coupling of N-pyridylindolines.: Direct carbonylation at a C-H bond δ to the pyridine nitrogen

被引：64

作者：

Chatani, N ^{[1
]}

Yorimitsu, S ^{[1
]}

Asaumi, T ^{[1
]}

Kakiuchi, F ^{[1
]}

Murai, S ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 21期

关键词：

D O I：

10.1021/jo0259865

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of N-pyridylindolines with CO and ethylene in the presence of Ru-3(CO)(12) results in direct carbonylation at a C-H bond delta to the pyridine sp(2) nitrogen, which represents a new type of C-H/CO/olefin coupling. The presence of a pyridine ring as a directing group on the substrates is essential for the reaction to proceed. The choice of N,N-dimethylacetamide (DMA) as the solvent is crucial for the reaction to proceed efficiently.

引用

页码：7557 / 7560

页数：4

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