Pyridine Derivatives of Acridine and Quinoline

被引：4
|
作者：
Akishina, E. A. [1 ]
Kazak, D. V. [1 ]
Dikusar, E. A. [1 ]
Alexeev, R. S. [2 ]
Bumagin, N. A. [2 ]
Potkin, V. I. [1 ]
机构：
[1] Natl Acad Sci Belarus, Inst Phys Organ Chem, Minsk 220072, BELARUS
[2] Lomonosov Moscow State Univ, Moscow 119991, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 12期
基金：
俄罗斯基础研究基金会;
关键词：
benzoacridines; pyrimidoquinolines; 2-naphthylamine; 2; 4; 6-trihydroxypyrimidine; cascade three-component condensation;
D O I：
10.1134/S1070363220120038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient one-pot approach was proposed for the synthesis of new derivatives of 8,9,10,12tetrahydrobenzo[a]acridin-11(7H)-one and 10,12-dihydrobenzo[f]pyrimido[4,5-b]quinoline-9,11(7H,8H)-dione containing residues of nicotinic and isonicotinic acids covalently attached via ester groups in different positions of the aromatic core. Quaternary ammonium salts of the synthesized acridine derivatives as well as a metal complex with palladium PdLCl2 were obtained. These compounds contain a number of pharmacophore groups so going to be promising potential drugs with antimicrobial, antiviral, and antitumor activity.
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页码：2230 / 2241
页数：12
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