Anti-inflammatory and anti-oxidant activities of Mallotus oppositifolius (Geisel) methanol leaf extracts

被引：15

作者：

Nwaehujor, Chinaka O. ^{[1
]}

Ezeja, Maxwell I. ^{[2
]}

Udeh, Nkeiruka E. ^{[2
]}

Okoye, Dozie N. ^{[3
]}

Udegbunam, Rita I. ^{[4
]}

机构：

[1] Univ Calabar, Dept Biochem, Calabar, Nigeria

[2] Michael Okpara Univ Agr, Dept Vet Physiol Pharmacol & Biochem, Umudike, Abia State, Nigeria

[3] Univ Nigeria, Fac Vet Med, Dept Vet Obstet & Reprod Dis, Nsukka, Enugu State, Nigeria

[4] Univ Nigeria, Dept Vet Surg, Nsukka, Enugu State, Nigeria

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2014年 / 7卷 / 05期

关键词：

Edema; Acetylsalicylate acid; Carrageenan; DPPH; FRAP; MEDICINE; EDEMA; PAW;

D O I：

10.1016/j.arabjc.2012.03.014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The methanol leaf extract of Mallotus oppositifolius was evaluated for anti-inflammatory activity in rats and mice using acute and chronic anti-inflammatory models with acetylsalicylate acid (aspirin) as the reference drug. The antioxidant activity was done in vitro using ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-hydrazyl (DPPH) spectrophotometric assays. The extract dose dependently and significantly reduced paw edema volume in rats induced by carrageenan (p<0.01), decreased croton oil-induced ear inflammation (p<0.05), inhibited cotton pellet-induced granuloma in mice and reduced the rat paw thickness in formalin-induced arthritis. (C) 2012 Production and hosting by Elsevier B. V. on behalf of King Saud University.

引用

页码：805 / 810

页数：6

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