Suppression of IL-10 production by calcitriol in patients with multiple sclerosis

被引：14
作者：
Niino, Masaaki [1 ]
Fukazawa, Toshiyuki [2 ]
Miyazaki, Yusei [1 ,3 ]
Takahashi, Eri [1 ]
Minami, Naoya [3 ]
Amino, Itaru [3 ]
Fujiki, Naoto [3 ]
Doi, Shizuki [3 ]
Kikuchi, Seiji [3 ]
机构：
[1] Hokkaido Med Ctr, Dept Clin Res, Sapporo, Hokkaido 0630005, Japan
[2] Sapporo Neurol Clin, Sapporo, Hokkaido, Japan
[3] Hokkaido Med Ctr, Dept Neurol, Sapporo, Hokkaido 0630005, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 270卷 / 1-2期
关键词：
Vitamin D; Multiple sclerosis; Cytokine; IL-10; Disability; CD4(+) T-CELLS; 1,25-DIHYDROXYVITAMIN D-3; VITAMIN-D; DENDRITIC CELLS; DOWN-REGULATION; DIFFERENTIATION; EXPRESSION; MONOCYTES; SYSTEM; TRIAL;
D O I：
10.1016/j.jneuroim.2014.03.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated whether calcitriol (1,25-dihydroxyvitamin D) differentially modulates cytokine production by peripheral blood mononuclear cells from multiple sclerosis (MS) patients compared with that from healthy controls. In response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS), cytokine level in a calcitriol-added sample was normalized to that in a calcitriol-absent sample, and this relative unit was compared. The relative unit of IL-12/23(p40) in LPS-stimulation was higher in MS patients. Moreover, the relative unit of IL-10 in PHA-stimulation was lower in MS patients, and negatively correlated with the Expanded Disability Status Scale. The anti-inflammatory response to vitamin D may be reduced in MS. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：86 / 94
页数：9
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