Mesenchymal Stem Cell Homing: The Devil Is in the Details

被引：1160
作者：
Karp, Jeffrey M. [1 ,2 ,3 ]
Teol, Grace Sock Leng [1 ,2 ,3 ,4 ]
机构：
[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[2] Brigham & Womens Hosp, Dept Med, HST Ctr Biomed Engn, Cambridge, MA 02139 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 639798, Singapore
来源：
CELL STEM CELL | 2009年 / 4卷 / 03期
关键词：
MARROW STROMAL CELLS; IMPROVES CARDIAC-PERFORMANCE; HUMAN BONE-MARROW; MYOCARDIAL-INFARCTION; PROGENITOR CELLS; ENDOTHELIAL-CELLS; P-SELECTIN; IN-VITRO; PROMOTING MIGRATION; MAGNETIC-RESONANCE;
D O I：
10.1016/j.stem.2009.02.001
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to promote regeneration of damaged tissue, to treat inflammation, and to promote angiogenesis. However, these studies are complicated by the diverse methods used to culture, characterize, and deliver MSCs and by the variety of methods used to assess homing events. This review provides a critical analysis of the methods used to track homing of exogenously infused MSCs and discusses strategies for enhancing their trafficking to particular tissues.
引用
收藏
页码：206 / 216
页数：11
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