Sarcoplasmic reticulum ATPase activity in type I and II skeletal muscle fibres of chronic heart failure patients

被引：11

作者：

Bekedam, Martijn A. ^{[2
]}

van Beek-Harmsen, Brechje J. ^{[1
]}

van Mechelen, Willem ^{[3
,4
]}

Boonstra, Anco ^{[5
]}

Visser, Frans C. ^{[2
]}

van der Laarse, Willem J. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res, Dept Physiol, NL-1081 BT Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res, Dept Cardiol, NL-1081 BT Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Social Med, NL-1081 BT Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, EMGO Inst, NL-1081 BT Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res, Dept Pulmonol, NL-1081 BT Amsterdam, Netherlands

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 133卷 / 02期

关键词：

Heart failure; Skeletal muscle; Sarcoplasmic reticulum ATPase; Myofibrillar ATPase; Succinate dehydrogenase; Biopsy; Exercise; SUCCINATE-DEHYDROGENASE; EXERCISE CAPACITY; THYROID-HORMONE; QUANTITATIVE HISTOCHEMISTRY; MYOFIBRILLAR ATPASE; OXYGEN-CONSUMPTION; FORCE PRODUCTION; MAXIMUM RATE; EXPRESSION; VENTILATION;

D O I：

10.1016/j.ijcard.2007.12.025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Reduced exercise tolerance and muscle weakness are present in patients with CHF. Altered metabolism, histology and function in skeletal muscle of patients with CHF have been reported. The sarcoplasmic reticulum (SR) has control of Ca++ release and uptake required for contraction and relaxation, respectively, and uses a considerable amount of energy. Little is known about SR alterations in CHF. We determined sarcoplasmic reticulum adenosine triphosphatase (SR ATPase) activity in different types of skeletal muscle fibres of CHF patients. Methods: SR ATPase activity, succinate dehydrogenase (SDH) activity and myofibrillar adenosine triphosphatase ( M ATPase) activity in single fibres of the vastus lateralis muscle in 16 CHF patients and 5 controls was determined using quantitative enzyme histochemistry. Results: SR ATPase activity of type II skeletal muscle fibers was significantly higher compared to type I fibres. SR ATPase activity in type II skeletal muscle fibres of CHF patients was higher than in control subjects. Conclusion: Increased skeletal muscle SR ATPase activity contributes to reduced exercise tolerance in CHF patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：185 / 190

页数：6

共 27 条

[1] Metabolism - Bile acids heat things up [J].