Mutation rates among RNA viruses

被引:858
作者
Drake, JW [1 ]
Holland, JJ
机构
[1] NIEHS, Mol Genet Lab, Res Triangle Pk, NC 27709 USA
[2] Univ Calif San Diego, Inst Genet Mol, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA
关键词
D O I
10.1073/pnas.96.24.13910
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The rate of spontaneous mutation is a key parameter in modeling the genetic structure and evolution of populations. The impact of the accumulated load of mutations and the consequences of increasing the mutation rate are important in assessing the genetic health of populations. Mutation frequencies are among the more directly measurable population parameters, although the information needed to convert them into mutation rates is often racking. A previous analysis of mutation rates in RNA viruses (specifically in riboviruses rather than retroviruses) was constrained by the quality and quantity of available measurements and by the lack of a specific theoretical framework for converting mutation frequencies into mutation rates in this group of organisms. Here, we describe a simple relation between ribovirus mutation frequencies and mutation rates, apply it to the best (albeit far from satisfactory) available data, and observe a central value for the mutation rate per genome per replication of mu(g) approximate to 0.76.(The rate per round of cell infection is twice this value or about 1.5.)This value is so large, and ribovirus genomes are so informationally dense, that even a modest increase extinguishes the population.
引用
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页码:13910 / 13913
页数:4
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