Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

被引：31

作者：

Venkateswarulu, M. ^{[1
]}

Mukherjee, Trinetra ^{[2
]}

Mukherjee, Subhrakanti ^{[2
]}

Koner, Rik Rani ^{[1
]}

机构：

[1] Indian Inst Technol Mandi, Sch Basic Sci, Mandi 175001, HP, India

[2] Univ Burdwan, Dept Microbiol, Burdwan 713104, W Bengal, India

来源：

DALTON TRANSACTIONS | 2014年 / 43卷 / 14期

关键词：

FLUORESCENT CHEMOSENSOR; LABILE IRON; SENSOR; FE3+; HYDROLYSIS; IRON(III); PROTEINS; COMPLEX; BIOLOGY; FE(III);

D O I：

10.1039/c3dt53141d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new turn-on cell permeable chemodosimetric probe 1 has been developed and its application in the selective detection of trivalent cations (Fe3+/Cr3+/Al3+) at a sub-nanomolar level has been demonstrated. The selectivity of 1 over a broad spectrum of mono-and divalent metal ions was established using fluorescence spectroscopy. Moreover, the changes in the absorption spectra of 1 in the presence of trivalent cations enabled the most bio-relevant metal ion Fe3+ over Cr3+/Al3+ to be distinguished. The probe was found to be successful in the fluorescence imaging of native cellular iron pools. The fluorescence imaging of the native iron pools of banana pith further supported the high sensitivity of 1 towards Fe3+ present in living systems. To the best of our knowledge, this is the first example of a turn-on chemodosimetric probe to image native cellular Fe3+ pools.

引用

页码：5269 / 5273

页数：5

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