Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective

被引：9

作者：

Rehrl, Jakob ^{[1
,2
]}

Gruber, Arlin ^{[2
]}

Khinast, Johannes G. ^{[2
,3
]}

Horn, Martin ^{[1
]}

机构：

[1] Graz Univ Technol, Inst Automat & Control, Inffeldgasse 21-B-1, A-8010 Graz, Austria

[2] Res Ctr Pharmaceut Engn GmbH, Inffeldgasse 13, A-8010 Graz, Austria

[3] Graz Univ Technol, Inst Particle & Proc Engn, Inffeldgasse 13-3, A-8010 Graz, Austria

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2017年 / 517卷 / 1-2期

关键词：

Sensitivity analysis; Pharmaceutical manufacturing; Dynamic systems; Process modeling; MODEL; COMPACTION; SYSTEMS; DESIGN; OPERATION; PAT;

D O I：

10.1016/j.ijpharm.2016.11.064

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper presents a sensitivity analysis of a pharmaceutical direct compaction process. Sensitivity analysis is an important tool for gaining valuable process insights and designing a process control concept. Examining its results in a systematic manner makes it possible to assign actuating signals to controlled variables. This paper presents mathematical models for individual unit operations, on which the sensitivity analysis is based. Two sensitivity analysis methods are outlined: (i) based on the so-called Sobol indices and (ii) based on the steady-state gains and the frequency response of the proposed plant model. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：373 / 382

页数：10

共 24 条

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