Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

被引：70

作者：

Belayev, L ^{[1
]}

Saul, I ^{[1
]}

Huh, PW ^{[1
]}

Finotti, N ^{[1
]}

Zhao, WZ ^{[1
]}

Busto, R ^{[1
]}

Ginsberg, MD ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Neurol, Cerebral Vasc Dis Res Ctr, Miami, FL 33101 USA

来源：

BRAIN RESEARCH | 1999年 / 845卷 / 01期

关键词：

albumin; global cerebral ischemia; neuroprotection; stroke;

D O I：

10.1016/S0006-8993(99)01952-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：107 / 111

页数：5

共 26 条

[1] Bilateral ischemic tolerance of rat hippocampus induced by prior unilateral transient focal ischemia: Relationship to c-fos mRNA expression [J].

Belayev, L ;

Ginsberg, MD ;

Alonso, OF ;

Singer, JT ;

Zhao, WZ ;

Busto, R .

NEUROREPORT, 1996, 8 (01) :55-59

[2] HU-211, A NONPSYCHOTROPIC CANNABINOID, IMPROVES NEUROLOGICAL SIGNS AND REDUCES BRAIN-DAMAGE AFTER SEVERE FOREBRAIN ISCHEMIA IN RATS [J].

BELAYEV, L ;

BARJOSEPH, A ;

ADAMCHIK, J ;

BIEGON, A .

MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1995, 25 (01) :19-33

[3] Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia [J].

Belayev, L ;

Zhao, WZ ;

Pattany, PM ;

Weaver, G ;

Huh, PW ;

Lin, BW ;

Busto, R ;

Ginsberg, MD .

STROKE, 1998, 29 (12) :2587-2598

[4] Posttreatment with high-dose albumin reduces histopathological damage and improves neurological deficit following fluid percussion brain injury in rats [J].

Belayev, L ;

Alonso, OF ;

Huh, PW ;

Zhao, WZ ;

Busto, R ;

Ginsberg, MD .

JOURNAL OF NEUROTRAUMA, 1999, 16 (06) :445-453

[5] Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats [J].

Belayev, L ;

Busto, R ;

Zhao, WZ ;

Clemens, JA ;

Ginsberg, MD .

JOURNAL OF NEUROSURGERY, 1997, 87 (04) :595-601

[6] POSTISCHEMIC MODERATE HYPOTHERMIA INHIBITS CA1 HIPPOCAMPAL ISCHEMIC NEURONAL INJURY [J].

BUSTO, R ;

DIETRICH, WD ;

GLOBUS, MYT ;

GINSBERG, MD .

NEUROSCIENCE LETTERS, 1989, 101 (03) :299-304

[7] NALOXONE EFFECT ON THE NEUROLOGICAL DEFICIT INDUCED BY FOREBRAIN ISCHEMIA IN RATS [J].

CAPDEVILLE, C ;

PRUNEAU, D ;

ALLIX, M ;

PLOTKINE, M ;

BOULU, RG .

LIFE SCIENCES, 1986, 38 (05) :437-442

[8] HYPERVOLEMIC HEMODILUTION MAY PROTECT THE RATS STRIATAL NEURONS FROM ISCHEMIC-INJURY BY REDUCING THE EXTRACELLULAR DOPAMINE [J].

CHIO, CC ;

HO, MT ;

HUANG, CC ;

JIN, YT ;

LIN, MT .

NEUROSCIENCE LETTERS, 1994, 171 (1-2) :5-8

[9] EFFECTS OF VISCOSITY AND OXYGEN-CONTENT ON CEREBRAL BLOOD-FLOW IN ISCHEMIC AND NORMAL RAT-BRAIN [J].

COLE, DJ ;

DRUMMOND, JC ;

PATEL, PM ;

MARCANTONIO, S .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1994, 124 (01) :15-20

[10] UNIQUE FEATURES OF ALBUMIN - A BRIEF REVIEW [J].

EMERSON, TE .

CRITICAL CARE MEDICINE, 1989, 17 (07) :690-694

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