MicroRNAs alteration as early biomarkers for cancer and neurodegenerative diseases: New challenges in pesticides exposure

被引：36
作者：
Costa, Chiara [1 ]
Teodoro, Michele [2 ]
Rugolo, Carmela Alessandra [2 ]
Alibrando, Carmela [2 ]
Giambo, Federica [2 ]
Briguglio, Giusi [2 ]
Fenga, Concettina [2 ]
机构：
[1] Univ Messina, Clin & Expt Med Dept, I-98125 Messina, Italy
[2] Univ Messina, Occupat Med Sect, Dept Biomed & Dent Sci & Morphofunct Imaging, I-98125 Messina, Italy
来源：
TOXICOLOGY REPORTS | 2020年 / 7卷
基金：
英国科研创新办公室;
关键词：
Pesticides; miRNA; Cancer; Neurodegenerative diseases; OCCUPATIONAL-EXPOSURE; HEPATOCELLULAR-CARCINOMA; GENETIC POLYMORPHISMS; POTENTIAL BIOMARKERS; PROGNOSTIC MARKERS; PARKINSONS-DISEASE; OXIDATIVE STRESS; DOWN-REGULATION; UP-REGULATION; AMYLOID-BETA;
D O I：
10.1016/j.toxrep.2020.05.003
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
This review summarizes the current knowledge linking cancer and neuro-degenerative diseases to dysregulation of microRNA network following pesticide exposure. Most findings revealed differential miRNA expression targeting biomolecules and pathways involved in various neoplastic localizations and neurodegenerative diseases. A growing body of evidence in recent literature indicates that alteration of specific miRNAs can represent an early biomarker of disease following exposure to chemical agents, including pesticides. Different miRNAs seem to regulate cell proliferation, apoptosis, migration, invasion, and metastasis via many biological pathways through modulation of the expression of target mRNAs. The evaluation of miRNA expression levels may be used to develop new non-invasive strategies for the prediction and prognosis of many diseases, including cancer. However, the application of miRNAs as diagnostic and therapeutic biomarkers in the clinical field is extremely challenging.
引用
收藏
页码：759 / 767
页数：9
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