An SHR-SCR module specifies legume cortical cell fate to enable nodulation

被引：103

作者：

Dong, Wentao ^{[1
,2
]}

Zhu, Yayun ^{[1
,3
]}

Chang, Huizhong ^{[1
,3
]}

Wang, Chunhua ^{[4
]}

Yang, Jun ^{[1
]}

Shi, Jincai ^{[1
,2
]}

Gao, Jinpeng ^{[1
,5
]}

Yang, Weibing ^{[1
]}

Lan, Liying ^{[1
,2
]}

Wang, Yuru ^{[1
,2
]}

Zhang, Xiaowei ^{[1
]}

Dai, Huiling ^{[1
]}

Miao, Yuchen ^{[5
]}

Xu, Lin ^{[1
]}

He, Zuhua ^{[1
]}

Song, Chunpeng ^{[5
]}

Wu, Shuang ^{[4
]}

Wang, Dong ^{[6
]}

Yu, Nan ^{[3
]}

Wang, Ertao ^{[1
]}

机构：

[1] Chinese Acad Sci, Natl Key Lab Plant Mol Genet, CAS Ctr Excellence Mol Plant Sci, Inst Plant Physiol & Ecol,SIBS, Shanghai, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Shanghai Normal Univ, Coll Life Sci, Shanghai Key Lab Plant Mol Sci, Shanghai, Peoples R China

[4] Fujian Agr & Forestry Univ, Coll Hort, Fuzhou, Peoples R China

[5] Henan Univ, Collaborat Innovat Ctr Crop Stress Biol, Inst Plant Stress Biol, State Key Lab Cotton Biol,Dept Biol, Kaifeng, Peoples R China

[6] Univ Massachusetts Amherst, Dept Biochem & Mol Biol, Amherst, MA USA

来源：

NATURE | 2021年 / 589卷 / 7843期

基金：

美国国家科学基金会; 国家重点研发计划;

关键词：

D O I：

10.1038/s41586-020-3016-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Legumes, unlike other plants, have the ability to establish symbiosis with nitrogen-fixing rhizobia. It has been theorized that a unique property of legume root cortical cells enabled the initial establishment of rhizobial symbiosis(1-3). Here we show that a SHORTROOT-SCARECROW (SHR-SCR) stem cell program in cortical cells of the legume Medicago truncatula specifies their distinct fate. Regulatory elements drive the cortical expression of SCR, and stele-expressed SHR protein accumulates in cortical cells of M. truncatula but not Arabidopsis thaliana. The cortical SHR-SCR network is conserved across legume species, responds to rhizobial signals, and initiates legume-specific cortical cell division for de novo nodule organogenesis and accommodation of rhizobia. Ectopic activation of SHR and SCR in legumes is sufficient to induce root cortical cell division. Our work suggests that acquisition of the cortical SHR-SCR module enabled cell division coupled to rhizobial infection in legumes. We propose that this event was central to the evolution of rhizobial endosymbiosis.

引用

页码：586 / +

页数：24

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