Efficient asymmetric hydrogenation of quinolines in neat water catalyzed by chiral cationic Ru-diamine complexes

被引：35
作者：
Yang, Zhusheng [1 ,2 ]
Chen, Fei [1 ]
He, Yan-Mei [1 ]
Yang, Nianfa [2 ]
Fan, Qing-Hua [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China
[2] Xiangtan Univ, Coll Chem, Key Lab Environmentally Friendly Chem, Minist Educ, Xiangtan 411105, Peoples R China
来源：
CATALYSIS SCIENCE & TECHNOLOGY | 2014年 / 4卷 / 09期
基金：
中国国家自然科学基金;
关键词：
HIGHLY ENANTIOSELECTIVE HYDROGENATION; BETA-KETO-ESTERS; AQUEOUS-MEDIA; ORGANIC-SYNTHESIS; AROMATIC KETONES; HETEROAROMATIC-COMPOUNDS; RUTHENIUM CATALYSTS; IRIDIUM COMPLEXES; GREEN CHEMISTRY; IONIC LIQUID;
D O I：
10.1039/c4cy00418c
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We describe herein highly effective asymmetric hydrogenation of quinolines in undegassed water catalyzed by chiral cationic Ru-diamine complexes for the first time. This facile and green protocol is applicable to the scaled-up synthesis of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline, a key intermediate for the preparation of the antibacterial agent (S)-flumequine, with 98% ee.
引用
收藏
页码：2887 / 2890
页数：4
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