CAR-T Cells for the Treatment of Lung Cancer

被引：13

作者：

Chocarro, Luisa ^{[1
]}

Arasanz, Hugo ^{[1
,2
]}

Fernandez-Rubio, Leticia ^{[1
]}

Blanco, Ester ^{[1
,3
]}

Echaide, Miriam ^{[1
]}

Bocanegra, Ana ^{[1
]}

Teijeira, Lucia ^{[2
]}

Garnica, Maider ^{[1
]}

Morilla, Idoia ^{[2
]}

Martinez-Aguillo, Maite ^{[2
]}

Pineiro-Hermida, Sergio ^{[1
]}

Ramos, Pablo ^{[1
]}

Lasarte, Juan Jose ^{[4
]}

Vera, Ruth ^{[2
,5
]}

Kochan, Grazyna ^{[1
]}

Escors, David ^{[1
]}

机构：

[1] Inst Inves Sanitaria Navarra IdiSNA, Navarrabiomed, Oncoimmunol Grp, Pamplona 31008, Spain

[2] Hosp Univ Navarra, Inst Invest Sanitaria Navarra IdiSNA, Dept Med Oncol, Pamplona 31008, Spain

[3] Inst Invest Sanitaria Navarra IdiSNA, Ctr Invest Med Aplicada CIMA, Div Gene Therapy & Regulat Gene Express, Pamplona 31008, Spain

[4] Inst Invest Sanitaria Navarra IdiSNA, Ctr Invest Med Aplicada CIMA, Immunol & Immunotherapy, Pamplona 31008, Spain

[5] Inst Invest Sanitaria Navarra IdiSNA, Oncobiona Grp, Navarrabiomed, Pamplona 31008, Spain

来源：

LIFE-BASEL | 2022年 / 12卷 / 04期

基金：

欧盟地平线“2020”;

关键词：

CAR-T; adoptive cell therapy; immunotherapy; solid tumors; lung cancer; IMMUNE CHECKPOINT BLOCKADE; CHIMERIC ANTIGEN RECEPTORS; ADOPTIVE IMMUNOTHERAPY; PHASE-I; EXPRESSION; ANTIBODY; THERAPY; TARGET; TUMORS; LYMPHOCYTES;

D O I：

10.3390/life12040561

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adoptive cell therapy with genetically modified T lymphocytes that express chimeric antigen receptors (CAR-T) is one of the most promising advanced therapies for the treatment of cancer, with unprecedented outcomes in hematological malignancies. However, the efficacy of CAR-T cells in solid tumors is still very unsatisfactory, because of the strong immunosuppressive tumor microenvironment that hinders immune responses. The development of next-generation personalized CAR-T cells against solid tumors is a clinical necessity. The identification of therapeutic targets for new CAR-T therapies to increase the efficacy, survival, persistence, and safety in solid tumors remains a critical frontier in cancer immunotherapy. Here, we summarize basic, translational, and clinical results of CAR-T cell immunotherapies in lung cancer, from their molecular engineering and mechanistic studies to preclinical and clinical development.

引用

页数：15

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