Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6TNF-/- Mice

被引：1
作者：
Karamova, A. E. [1 ]
Semenova, V. G. [1 ]
Verbenko, D. A. [1 ]
Obraztsova, O. A. [1 ]
Vanchugova, Kh. M. [1 ]
Nikonorov, A. A. [1 ]
Deryabin, D. G. [1 ]
Solomka, V. S. [1 ]
Kubanov, A. A. [1 ]
机构：
[1] Minist Hlth Russian Federat, State Res Ctr Dermatovenereol & Cosmetol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 06期
关键词：
leprosy; Mycobacterium leprae; mice; real time PCR;
D O I：
10.1007/s10517-020-04991-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6TNF(-/-) mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6TNF(-/-) mice.
引用
收藏
页码：836 / 839
页数：4
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