Clues to VIP function from knockout mice

被引：18

作者：

Hamidi, S. A.

Szema, A. M.

Lyubsky, S.

Dickman, K. G.

Degene, A.

Mathew, S. M.

Waschek, J. A.

Said, S. I. ^{[1
]}

机构：

[1] SUNY Stony Brook, Hlth Sci Ctr, Stony Brook, NY 11794 USA

[2] Vet Adm Med Ctr, Northport, NY 11768 USA

[3] Univ Calif Los Angeles, Med Ctr, Los Angeles, CA 90095 USA

来源：

VIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY | 2006年 / 1070卷

关键词：

VIP; lung; bronchial asthma; endotoxemia; septic shock; pulmonary circulation; knockout mice;

D O I：

10.1196/annals.1317.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: (a) airway reactivity and airway inflammation, as indicators of bronchial asthma; (b) mortality from endotoxemia, a model of septic shock; and (c) the pulmonary circulation. VIP KO mice showed: (a) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; (b) a greater susceptibility to death from endotoxemia; and (c) evidence suggestive of pulmonary hypertension.

引用

页码：5 / 9

页数：5

共 8 条

[1] ELEVATED VIP AND ENDOTOXIN PLASMA-LEVELS IN HUMAN GRAM-NEGATIVE SEPTIC SHOCK [J].