Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major

被引：5
作者：
Oza, Sandra L. [1 ]
Wyllie, Susan [1 ]
Fairlamb, Alan H. [1 ]
机构：
[1] Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2006年 / 149卷 / 01期
基金：
英国惠康基金;
关键词：
synthetase; domain; GlobPlot; trypanothione; thiol; trypanosome;
D O I：
10.1016/j.molbiopara.2006.05.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：117 / 120
页数：4
相关论文
共 13 条
[1]   Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosorne [J].
Ariyanayagam, MR ;
Oza, SL ;
Guther, MLS ;
Fairlamb, AH .
BIOCHEMICAL JOURNAL, 2005, 391 :425-432
[2]   Trypanothione synthesis in Crithidia revisited [J].
Comini, M ;
Menge, U ;
Wissing, J ;
Flohé, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (08) :6850-6860
[3]   Validation of Trypanosoma brucei trypanothione synthetase as drug target [J].
Comini, MA ;
Guerrero, SA ;
Haile, S ;
Menge, U ;
Lünsdorf, H ;
Flohé, L .
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 36 (10) :1289-1302
[4]   INVIVO EFFECTS OF DIFLUOROMETHYLORNITHINE ON TRYPANOTHIONE AND POLYAMINE LEVELS IN BLOOD-STREAM FORMS OF TRYPANOSOMA-BRUCEI [J].
FAIRLAMB, AH ;
HENDERSON, GB ;
BACCHI, CJ ;
CERAMI, A .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 24 (02) :185-191
[5]  
Kwon DS, 1997, J BIOL CHEM, V272, P2429
[6]  
Lee YT, 2000, B KOR CHEM SOC, V21, P953
[7]   GlobPlot: exploring protein sequences for globularity and disorder [J].
Linding, R ;
Russell, RB ;
Neduva, V ;
Gibson, TJ .
NUCLEIC ACIDS RESEARCH, 2003, 31 (13) :3701-3708
[8]   Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata [J].
Oza, SL ;
Ariyanayagam, MR ;
Fairlamb, AH .
BIOCHEMICAL JOURNAL, 2002, 364 :679-686
[9]   A single enzyme catalyses formation of trypanothione from glutathione and spermidine in Trypanosoma cruzi [J].
Oza, SL ;
Tetaud, E ;
Ariyanayagam, MR ;
Warnon, SS ;
Fairlamb, AH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (39) :35853-35861
[10]   Trypanothione biosynthesis in Leishmania major [J].
Oza, SL ;
Shaw, MP ;
Wyllie, S ;
Fairlamb, AH .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2005, 139 (01) :107-116
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