Aplysinellamides A-C, Bromotyrosine-Derived Metabolites from an Australian Aplysinella sp Marine Sponge

被引：20

作者：

Tian, Li-Wen ^{[1
]}

Feng, Yunjiang ^{[1
]}

Shimizu, Yoko ^{[2
]}

Pfeifer, Tom ^{[2
]}

Wellington, Cheryl ^{[3
]}

Hooper, John N. A. ^{[4
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Ctr Drug Res & Dev, Vancouver, BC 2405, Canada

[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V6T 1Z4, Canada

[4] Queensland Museum, South Brisbane, Qld 4101, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; ALKALOIDS; THERAPEUTICS;

D O I：

10.1021/np500119e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Mass-directed fractionation of an extract from the Australian marine sponge Aplysinella sp., from the Great Barrier Reef, resulted in the isolation of four new bromotyrosine derivatives, aplysinellamides A-C (1-3) and aplysamine-1-N-oxide (4), along with six known compounds (5-10). The structure elucidation of compounds 1-4 was based on their 1D and 2D NMR and MS spectroscopic data. Aplysamine-1 (6) increased the apolipoprotein E secretion from human CCF-STTG1 astrocytoma cells by 2-fold at the concentration of 30 mu M.

引用

页码：1210 / 1214

页数：5

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