Modulation of Taste Responsiveness by Angiotensin II

Angiotensin II and aldosterone are key hormones regulating sodium and water balance. Investigations of the taste system in rat have shown that the amiloride-sensitivity of the taste nerve responses to NaCl is enhanced by aldosterone treatment over a time course of several hours. A recent study further revealed that angiotensin II suppresses the amiloride-sensitivity of the mouse gustatory NaCl responses and enhances sweet taste sensitivity within one hour, without affecting umami, sour and bitter responses. These results suggest the presence of a reciprocal regulatory mechanism of salty taste sensitivity by angiotensin II as an acute suppressor and aldosterone as a slow enhancer in peripheral taste organs, which may play an important role in maintaining sodium homeostasis. Moreover, the possible cross-talk between salty and sweet taste modulation by angiotensin II signaling may optimize sodium and calorie intake.