Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer

被引：74

作者：

Namikawa, Tsutomu ^{[1
]}

Ishida, Nobuko ^{[1
]}

Tsuda, Sachi ^{[1
]}

Fujisawa, Kazune ^{[1
]}

Munekage, Eri ^{[1
]}

Iwabu, Jun ^{[1
]}

Munekage, Masaya ^{[1
]}

Uemura, Sunao ^{[1
]}

Tsujii, Shigehiro ^{[1
]}

Tamura, Takahiko ^{[2
]}

Yatabe, Tomoaki ^{[2
]}

Maeda, Hiromichi ^{[3
]}

Kitagawa, Hiroyuki ^{[1
]}

Kobayashi, Michiya ^{[3
,4
]}

Hanazaki, Kazuhiro ^{[1
]}

机构：

[1] Kochi Med Sch, Dept Surg, Oko Cho, Nankoku, Kochi 7838505, Japan

[2] Kochi Med Sch, Dept Anesthesiol & Intens Care Med, Kochi, Japan

[3] Kochi Med Sch Hosp, Canc Treatment Ctr, Kochi, Japan

[4] Kochi Med Sch, Dept Human Hlth & Med Sci, Kochi, Japan

来源：

GASTRIC CANCER | 2019年 / 22卷 / 04期

关键词：

Alkaline phosphatase; Lactate dehydrogenase; Gastric cancer; Prognostic value; Survival; SYSTEMIC INFLAMMATORY RESPONSE; SCORE; CLASSIFICATION; SURVIVAL; CHEMOTHERAPY; EXPRESSION; LIVER; LUNG; LDH;

D O I：

10.1007/s10120-018-0897-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThis study evaluated the prognostic value of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) together with host-related factors in patients with unresectable advanced gastric cancer.MethodsThe study enrolled 262 patients who received chemotherapy for unresectable advanced gastric cancer at Kochi Medical School from 2007 to 2015. Clinicopathological information and systemic inflammatory response data were analyzed for associations between baseline cancer-related prognostic variables and survival outcomes.ResultsThe median survival time was significantly lower for patients with high ALP, high LDH, high total bilirubin, high aspartate aminotransferase, high alanine transaminase, high gamma-glutamyltransferase, high creatinine, a Glasgow prognostic score (GPS) of 1 or 2 score compared to GPS 0, higher compared to lower neutrophil to lymphocyte ratio (NLR) 3.9, lower compared to higher prognostic nutrition index 36.1, T3-4 compared to T1-2 tumor and diffuse-type compared to intestinal-type histology. Multivariate survival analysis identified high ALP 322 (HR 1.808; 95% CI 1.015-3.220; P=0.044), T2-3 (HR 2.622; 95% CI 1.224-5.618; P=0.013), and diffuse-type gastric cancer (HR 2.325; 95% CI 1.341-4.032; P=0.003) as significant independent predictors of worse prognosis in the studied group of cancer patients.ConclusionsHigh level of ALP is an independent, worse prognosis factor for patients receiving chemotherapy for unresectable and recurrent gastric cancer.

引用

页码：684 / 691

页数：8

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