Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer

被引：74

作者：

Namikawa, Tsutomu ^{[1
]}

Ishida, Nobuko ^{[1
]}

Tsuda, Sachi ^{[1
]}

Fujisawa, Kazune ^{[1
]}

Munekage, Eri ^{[1
]}

Iwabu, Jun ^{[1
]}

Munekage, Masaya ^{[1
]}

Uemura, Sunao ^{[1
]}

Tsujii, Shigehiro ^{[1
]}

Tamura, Takahiko ^{[2
]}

Yatabe, Tomoaki ^{[2
]}

Maeda, Hiromichi ^{[3
]}

Kitagawa, Hiroyuki ^{[1
]}

Kobayashi, Michiya ^{[3
,4
]}

Hanazaki, Kazuhiro ^{[1
]}

机构：

[1] Kochi Med Sch, Dept Surg, Oko Cho, Nankoku, Kochi 7838505, Japan

[2] Kochi Med Sch, Dept Anesthesiol & Intens Care Med, Kochi, Japan

[3] Kochi Med Sch Hosp, Canc Treatment Ctr, Kochi, Japan

[4] Kochi Med Sch, Dept Human Hlth & Med Sci, Kochi, Japan

来源：

GASTRIC CANCER | 2019年 / 22卷 / 04期

关键词：

Alkaline phosphatase; Lactate dehydrogenase; Gastric cancer; Prognostic value; Survival; SYSTEMIC INFLAMMATORY RESPONSE; SCORE; CLASSIFICATION; SURVIVAL; CHEMOTHERAPY; EXPRESSION; LIVER; LUNG; LDH;

D O I：

10.1007/s10120-018-0897-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThis study evaluated the prognostic value of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) together with host-related factors in patients with unresectable advanced gastric cancer.MethodsThe study enrolled 262 patients who received chemotherapy for unresectable advanced gastric cancer at Kochi Medical School from 2007 to 2015. Clinicopathological information and systemic inflammatory response data were analyzed for associations between baseline cancer-related prognostic variables and survival outcomes.ResultsThe median survival time was significantly lower for patients with high ALP, high LDH, high total bilirubin, high aspartate aminotransferase, high alanine transaminase, high gamma-glutamyltransferase, high creatinine, a Glasgow prognostic score (GPS) of 1 or 2 score compared to GPS 0, higher compared to lower neutrophil to lymphocyte ratio (NLR) 3.9, lower compared to higher prognostic nutrition index 36.1, T3-4 compared to T1-2 tumor and diffuse-type compared to intestinal-type histology. Multivariate survival analysis identified high ALP 322 (HR 1.808; 95% CI 1.015-3.220; P=0.044), T2-3 (HR 2.622; 95% CI 1.224-5.618; P=0.013), and diffuse-type gastric cancer (HR 2.325; 95% CI 1.341-4.032; P=0.003) as significant independent predictors of worse prognosis in the studied group of cancer patients.ConclusionsHigh level of ALP is an independent, worse prognosis factor for patients receiving chemotherapy for unresectable and recurrent gastric cancer.

引用

页码：684 / 691

页数：8

共 33 条

[1]

Bang YJ, 2010, LANCET, V376, P1302

[2] Pathohistological classification systems in gastric cancer: Diagnostic relevance and prognostic value [J].

Berlth, Felix ;

Bollschweiler, Elfriede ;

Drebber, Uta ;

Hoelscher, Arnulf H. ;

Moenig, Stefan .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (19) :5679-5684

[3] Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study [J].

Boku, Narikazu ;

Yamamoto, Seiichiro ;

Fukuda, Haruhiko ;

Shirao, Kuniaki ;

Doi, Toshihiko ;

Sawaki, Akira ;

Koizumi, Wasaburo ;

Saito, Hiroshi ;

Yamaguchi, Kensei ;

Takiuchi, Hiroya ;

Nasu, Junichiro ;

Ohtsu, Atsushi .

LANCET ONCOLOGY, 2009, 10 (11) :1063-1069

[4] The relationship between an inflammation-based prognostic score (Glasgow Prognostic Score) and changes in serum biochemical variables in patients with advanced lung and gastrointestinal cancer [J].

Brown, D. J. F. ;

Milroy, R. ;

Preston, T. ;

McMillan, D. C. .

JOURNAL OF CLINICAL PATHOLOGY, 2007, 60 (06) :705-708

[5] Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein [J].

Dua, Pooja ;

Kang, Hye Suk ;

Hong, Seung-Mo ;

Tsao, Ming-Sound ;

Kim, Soyoun ;

Lee, Dong-ki .

CANCER RESEARCH, 2013, 73 (06) :1934-1945

[6] The value of lactate dehydrogenase serum levels as a prognostic and predictive factor for advanced pancreatic cancer patients receiving sorafenib [J].

Faloppi, Luca ;

Bianconi, Maristella ;

Giampieri, Riccardo ;

Sobrero, Alberto ;

Labianca, Roberto ;

Ferrari, Daris ;

Barni, Sandro ;

Aitini, Enrico ;

Zaniboni, Alberto ;

Boni, Corrado ;

Caprioni, Francesco ;

Mosconi, Stefania ;

Fanello, Silvia ;

Berardi, Rossana ;

Bittoni, Alessandro ;

Andrikou, Kalliopi ;

Cinquini, Michela ;

Torri, Valter ;

Scartozzi, Mario ;

Cascinu, Stefano .

ONCOTARGET, 2015, 6 (33) :35087-35094

[7] Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance [J].

Fantin, Valeria R. ;

St-Pierre, Julie ;

Leder, Philip .

CANCER CELL, 2006, 9 (06) :425-434

[8] Metabolic reprogramming of the tumor [J].

Ferreira, L. M. R. ;

Hebrant, A. ;

Dumont, J. E. .

ONCOGENE, 2012, 31 (36) :3999-4011

[9] Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study [J].

Fidler, Miranda M. ;

Gupta, Sumit ;

Soerjomataram, Isabelle ;

Ferlay, Jacques ;

Steliarova-Foucher, Eva ;

Bray, Freddie .

LANCET ONCOLOGY, 2017, 18 (12) :1579-1589

[10] Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer [J].

Forrest, LM ;

McMillan, DC ;

McArdle, CS ;

Angerson, WJ ;

Dunlop, DJ .

BRITISH JOURNAL OF CANCER, 2003, 89 (06) :1028-1030

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