CAR-T cells: the long and winding road to solid tumors

被引：311
作者：
D'Aloia, Maria Michela [1 ]
Zizzari, Ilaria Grazia [2 ]
Sacchetti, Benedetto [3 ]
Pierelli, Luca [2 ]
Alimandi, Maurizio [1 ]
机构：
[1] Sapienza Univ Rome, Dept Clin & Mol Med, Rome, Italy
[2] Sapienza Univ Rome, Dept Expt Med, Rome, Italy
[3] Univ Roma Tre, Dept Sci, Rome, Italy
来源：
CELL DEATH & DISEASE | 2018年 / 9卷
关键词：
CHIMERIC ANTIGEN RECEPTOR; MONOCLONAL-ANTIBODY THERAPY; I CLINICAL-TRIAL; SLEEPING-BEAUTY; INFILTRATING LYMPHOCYTES; ANTITUMOR-ACTIVITY; IMPROVED SURVIVAL; ADOPTIVE TRANSFER; OXIDATIVE STRESS; EFFECTOR-CELLS;
D O I：
10.1038/s41419-018-0278-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the "next generation" of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the inability to reach and survive in the microenvironment surrounding the neoplastic foci. The intricate net of cross-interactions occurring between tumor components, stromal and immune cells leads to an ineffective anergic status favoring the evasion from the host's defenses. Our goal is hereby to trace the road imposed by solid tumors to CAR-T cells, highlighting pitfalls and strategies to be developed and refined to possibly overcome these hurdles.
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页数：12
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共 108 条
  • [1] Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
    Ahmed, Nabil
    Brawley, Vita S.
    Hegde, Meenakshi
    Robertson, Catherine
    Ghazi, Alexia
    Gerken, Claudia
    Liu, Enli
    Dakhova, Olga
    Ashoori, Aidin
    Corder, Amanda
    Gray, Tara
    Wu, Meng-Fen
    Liu, Hao
    Hicks, John
    Rainusso, Nino
    Dotti, Gianpietro
    Mei, Zhuyong
    Grilley, Bambi
    Gee, Adrian
    Rooney, Cliona M.
    Brenner, Malcolm K.
    Heslop, Helen E.
    Wels, Winfried S.
    Wang, Lisa L.
    Anderson, Peter
    Gottschalk, Stephen
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15) : 1688 - +
  • [2] TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β
    Arumugam, Vidhyalakshmi
    Bluemn, Theresa
    Wesley, Erin
    Schmidt, Amanda M.
    Kambayashi, Taku
    Malarkannan, Subramaniam
    Riese, Matthew J.
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 98 (05) : 703 - 712
  • [3] Badhiwala J, 2013, EXPERT REV NEUROTHER, V13, P405, DOI [10.1586/ern.13.23, 10.1586/ERN.13.23]
  • [4] Fc Receptor-Dependent Mechanisms of Monoclonal Antibody Therapy of Cancer
    Bakema, Jantine E.
    van Egmond, Marjolein
    [J]. FC RECEPTORS, 2014, 382 : 373 - 392
  • [5] Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
    Beatty, Gregory L.
    Haas, Andrew R.
    Maus, Marcela V.
    Torigian, Drew A.
    Soulen, Michael C.
    Plesa, Gabriela
    Chew, Anne
    Zhao, Yangbing
    Levine, Bruce L.
    Albelda, Steven M.
    Kalos, Michael
    June, Carl H.
    [J]. CANCER IMMUNOLOGY RESEARCH, 2014, 2 (02) : 112 - 120
  • [6] Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients
    Besser, Michal J.
    Shapira-Frommer, Ronnie
    Treves, Avraham J.
    Zippel, Dov
    Itzhaki, Orit
    Hershkovitz, Liat
    Levy, Daphna
    Kubi, Adva
    Hovav, Einat
    Chermoshniuk, Natalia
    Shalmon, Bruria
    Hardan, Izhar
    Catane, Raphael
    Markel, Gal
    Apter, Sara
    Ben-Nun, Alon
    Kuchuk, Iryna
    Shimoni, Avichai
    Nagler, Arnon
    Schachter, Jacob
    [J]. CLINICAL CANCER RESEARCH, 2010, 16 (09) : 2646 - 2655
  • [7] Minimally Cultured or Selected Autologous Tumor-infiltrating Lymphocytes After a Lympho-depleting Chemotherapy Regimen in Metastatic Melanoma Patients
    Besser, Michal J.
    Shapira-Frommer, Ronnie
    Treves, Avraham J.
    Zippel, Dov
    Itzhaki, Orit
    Schallmach, Ester
    Kubi, Adva
    Shalmon, Bruria
    Hardan, Izhar
    Catane, Raphael
    Segal, Eran
    Markel, Gal
    Apter, Sara
    Ben Nun, Alon
    Kuchuk, Iryna
    Shimoni, Avichai
    Nagler, Arnon
    Schachter, Jacob
    [J]. JOURNAL OF IMMUNOTHERAPY, 2009, 32 (04) : 415 - 423
  • [8] Adapting a transforming growth factor β-related tumor protection strategy to enhance antitumor immunity
    Bollard, CM
    Rössig, C
    Calonge, MJ
    Huls, MH
    Wagner, HJ
    Massague, J
    Brenner, MK
    Heslop, HE
    Rooney, CM
    [J]. BLOOD, 2002, 99 (09) : 3179 - 3187
  • [9] Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
    Bracci, L.
    Schiavoni, G.
    Sistigu, A.
    Belardelli, F.
    [J]. CELL DEATH AND DIFFERENTIATION, 2014, 21 (01) : 15 - 25
  • [10] Myeloid cells as effector cells for monoclonal antibody therapy of cancer
    Braster, Rens
    O'Toole, Tom
    van Egmond, Marjolein
    [J]. METHODS, 2014, 65 (01) : 28 - 37
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