Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats

被引：34

作者：

Brandt, Joyce Zalotti ^{[1
]}

Silveira, Livia Teresa R. ^{[1
]}

Grassi, Tony Fernando ^{[2
]}

Anselmo-Franci, Janete A. ^{[3
]}

Favaro, Wagner Jose ^{[4
]}

Felisbino, Sergio Luis ^{[1
]}

Barbisan, Luis Fernando ^{[1
]}

Scarano, Wellerson Rodrigo ^{[1
]}

机构：

[1] Sao Paulo State Univ, Inst Biosci, Dept Morphol, UNESP, BR-18618970 Botucatu, SP, Brazil

[2] UNESP, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP, Brazil

[3] Univ Sao Paulo FORP USP, Fac Dent, BR-14040904 Ribeirao Preto, SP, Brazil

[4] Univ Estadual Campinas, UNICAMP, Inst Biol, BR-13083862 Campinas, SP, Brazil

来源：

REPRODUCTIVE TOXICOLOGY | 2014年 / 43卷

基金：

巴西圣保罗研究基金会;

关键词：

Bisphenol A; Prostate; Inflammation; Indole-3-carbinol; Chemoprevention; Reproductive toxicology; DEVELOPMENTAL EXPOSURE; LATERAL PROSTATE; VENTRAL PROSTATE; ESTROGEN; EXPRESSION; ESTRADIOL; CARCINOGENESIS; MODELS; LUNG; HYPERPLASIA;

D O I：

10.1016/j.reprotox.2013.11.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：56 / 66

页数：11

共 72 条

[51] Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: Proliferative and inflammatory disorders and a possible role of androgens [J].

Scarano, Wellerson Rodrigo ;

de Toledo, Fabiola Choqueta ;

Guerra, Marina Trevizan ;

Pegorin de Campos, Silvana Gisele ;

Justulin Junior, Luis Antonio ;

Felisbino, Sergio Luis ;

Anselmo-Franci, Janete A. ;

Taboga, Sebastiao Roberto ;

Kempinas, Wilma De Grava .

TOXICOLOGY, 2009, 262 (03) :215-223

[52] Tissue remodeling in Guinea pig lateral prostate at different ages after estradiol treatment [J].

Scarano, WR ;

Cordeiro, RS ;

Góes, RM ;

Carvalho, HF ;

Taboga, SR .

CELL BIOLOGY INTERNATIONAL, 2005, 29 (09) :778-784

[53] Prostate pathology of genetically engineered mice: Definitions and classification. The consensus report from the bar harbor meeting of the mouse models of human cancer consortium prostate pathology committee [J].

Shappell, SB ;

Thomas, GV ;

Roberts, RL ;

Herbert, R ;

Ittmann, MM ;

Rubin, MA ;

Humphrey, PA ;

Sundberg, JP ;

Rozengurt, N ;

Barrios, R ;

Ward, JM ;

Cardiff, RD .

CANCER RESEARCH, 2004, 64 (06) :2270-2305

[54] Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice [J].

Souli, Einat ;

Machluf, Marcelle ;

Morgenstern, Abigail ;

Sabo, Edmond ;

Yannai, Shmuel .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (03) :863-870

[55] The environmental estrogen bisphenol a stimulates prolactin release in vitro and in vivo [J].

Steinmetz, R ;

Brown, NG ;

Allen, DL ;

Bigsby, RM ;

BenJonathan, N .

ENDOCRINOLOGY, 1997, 138 (05) :1780-1786

[56] Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection [J].

Sun, Y ;

Irie, M ;

Kishikawa, N ;

Wada, M ;

Kuroda, N ;

Nakashima, K .

BIOMEDICAL CHROMATOGRAPHY, 2004, 18 (08) :501-507

[57] Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells [J].

Sundar, Shyam N. ;

Kerekatte, Vaishali ;

Equinozio, Caterina N. ;

Doan, Victor B. ;

Bjeldanes, Leonard F. ;

Firestone, Gary L. .

MOLECULAR ENDOCRINOLOGY, 2006, 20 (12) :3070-3082

[58] Neonatal Exposure to Estradiol/Bisphenol A Alters Promoter Methylation and Expression of Nsbp1 and Hpcal1 Genes and Transcriptional Programs of Dnmt3a/b and Mbd2/4 in the RatProstate Gland Throughout Life [J].

Tang, Wan-yee ;

Morey, Lisa M. ;

Cheung, Yuk Yin ;

Birch, Lynn ;

Prins, Gail S. ;

Ho, Shuk-mei .

ENDOCRINOLOGY, 2012, 153 (01) :42-55

[59] EFFECT OF PUBERTAL DEVELOPMENT ON ESTROGEN-RECEPTOR LEVELS AND STROMAL MORPHOLOGY IN THE GUINEA-PIG PROSTATE [J].

TILLEY, WD ;

HORSFALL, DJ ;

SKINNER, JM ;

HENDERSON, DW ;

MARSHALL, VR .

PROSTATE, 1989, 15 (02) :195-210

[60] Postnatal growth of the ventral prostate in Wistar rats: A stereological and morphometrical study [J].

Vilamaior, Patricia S. L. ;

Taboga, Sebastiao R. ;

Carvalho, Hernandes F. .

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY, 2006, 288A (08) :885-892

← 1 2 3 4 5 6 7 8 →