Anallysfis on the Pollymorphiism of Chromosome Region 9p21 and the allsceptiblinty of Cavotkl Plaque

被引:3
作者
Sun, Jialan [1 ]
Sun, Fenghua [4 ]
Yang, Kang [2 ,3 ]
Fu, Ningzhen [2 ,3 ]
Li, Longxuan [1 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Neurol, Gongli Hosp, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Neurol, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Inst Neurol, Rui Jin Hosp, Sch Med, Shanghai, Peoples R China
[4] First Peoples Hosp Tonglu Cty, Dept Neurol, Hangzhou, Zhejiang, Peoples R China
关键词
Cerebral infarction; Single nucleotide polymorphism; 9p21; Carotid plaque; SINGLE-NUCLEOTIDE POLYMORPHISMS; CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; ISCHEMIC-STROKE; RISK-ASSESSMENT; ASSOCIATION; VARIANTS; ATHEROSCLEROSIS; INFARCTION; MARKERS;
D O I
10.1159/000452970
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Atherosclerosis is a complicated disease governed by genetic, environmental and vascular risk factors, while its relationship with specific genes is still unclear. In recent days, it has been discovered that the single-nucleotide polymorphisms of chromosomal region 9p21 were relevant with the genetic susceptibility of Atherosclerosis. We aimed to figure out the relativity between the gene polymorphism of region 9p21 (rs10757274, rs7044859, rs4977574 and rs496892) and carotid plaque. Methods: With polymerase chain reaction-ligase detection reaction, the gene polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in chromosome region 9p21 were analyzed in 764 non-cardiac cerebral infarction (CI) patients (406 with carotid plaque while 358 without). Results: Among the population aged between 45 and 65, compared to patients without carotid plaque, no significant difference were observed on the genotype or allele frequencies distribution in 9p21 genes including rs10757274, rs7044859, rs4977574 and rs496892 in the patients with carotid plaque. There existed strong linkage disequilibrium not only between rs10757274 and rs4977574 but also between rs7044859 and rs496892 as well. Conclusion: In Chinese Han CI population, there was no significant relevance between the polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in region 9p21 and the susceptibility of carotid plaque. (C) 2016 S. Karger AG, Basel
引用
收藏
页码:25 / 31
页数:7
相关论文
共 28 条
  • [1] Genetic Mechanisms Mediating Atherosclerosis Susceptibility at the Chromosome 9p21 Locus
    Cunnington, Michael S.
    Keavney, Bernard
    [J]. CURRENT ATHEROSCLEROSIS REPORTS, 2011, 13 (03) : 193 - 201
  • [2] Carotid artery atherosclerosis: What is the evidence for drug action?
    Daskalopoulou, Stella S.
    Daskalopoulos, Marios E.
    Perrea, Despina
    Nicolaides, Andrew N.
    Liapis, Christos D.
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (11) : 1141 - 1159
  • [3] More SNPs on the way
    Garber, K
    [J]. SCIENCE, 1998, 281 (5384) : 1788 - 1788
  • [4] Single-nucleotide polymorphisms at the 9p21.3 genomic region not associated with the risk of cardiovascular disease in patients with rheumatoid arthritis
    Garcia-Bermudez, M.
    Lopez-Mejias, R.
    Genre, F.
    Castaneda, S.
    Gonzalez-Juanatey, C.
    Llorca, J.
    Corrales, A.
    Miranda-Filloy, J. A.
    Pina, T.
    Gomez-Vaquero, C.
    Rodriguez-Rodriguez, L.
    Fernandez-Gutierrez, B.
    Pascual-Salcedo, D.
    Balsa, A.
    Lopez-Longo, F. J.
    Carreira, P.
    Blanco, R.
    Gonzalez-Alvaro, I.
    Martin, J.
    Gonzalez-Gay, M. A.
    [J]. TISSUE ANTIGENS, 2013, 82 (06): : 405 - 409
  • [5] Rheumatoid arthritis: A disease associated with accelerated atherogenesis
    Gonzalez-Gay, MA
    Gonzalez-Juanatey, C
    Martin, J
    [J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 2005, 35 (01) : 8 - 17
  • [6] Sequence Variants on Chromosome 9p21.3 Confer Risk for Atherosclerotic Stroke
    Gschwendtner, Andreas
    Bevan, Steve
    Cole, John W.
    Plourde, Anna
    Matarin, Mar
    Ross-Adams, Helen
    Meitinger, Thomas
    Wichmann, Erich
    Mitchell, Braxton D.
    Furie, Karen
    Slowik, Agnieszka
    Rich, Stephen S.
    Syme, Paul D.
    MacLeod, Mary J.
    Meschia, James F.
    Rosand, Jonathan
    Kittner, Steve J.
    Markus, Hugh S.
    Mueller-Myhsok, Bertram
    Dichgans, Martin
    [J]. ANNALS OF NEUROLOGY, 2009, 65 (05) : 531 - 539
  • [7] Carotid plaque formation and serum biomarkers
    Hermus, Linda
    Lefrandt, Joop D.
    Tio, Rene A.
    Breek, Jan-Cees
    Zeebregts, Clark J.
    [J]. ATHEROSCLEROSIS, 2010, 213 (01) : 21 - 29
  • [8] MOLECULAR BIOLOGY OF ATHEROSCLEROSIS
    Hopkins, Paul N.
    [J]. PHYSIOLOGICAL REVIEWS, 2013, 93 (03) : 1317 - 1542
  • [9] Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene
    Kotake, Y.
    Nakagawa, T.
    Kitagawa, K.
    Suzuki, S.
    Liu, N.
    Kitagawa, M.
    Xiong, Y.
    [J]. ONCOGENE, 2011, 30 (16) : 1956 - 1962
  • [10] A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn)
    Li, Zhiqiang
    Zhang, Zhao
    He, Zangdong
    Tang, Wei
    Li, Tao
    Zeng, Zhen
    He, Lin
    Shi, Yongyong
    [J]. CELL RESEARCH, 2009, 19 (04) : 519 - 523