Background: Atherosclerosis is a complicated disease governed by genetic, environmental and vascular risk factors, while its relationship with specific genes is still unclear. In recent days, it has been discovered that the single-nucleotide polymorphisms of chromosomal region 9p21 were relevant with the genetic susceptibility of Atherosclerosis. We aimed to figure out the relativity between the gene polymorphism of region 9p21 (rs10757274, rs7044859, rs4977574 and rs496892) and carotid plaque. Methods: With polymerase chain reaction-ligase detection reaction, the gene polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in chromosome region 9p21 were analyzed in 764 non-cardiac cerebral infarction (CI) patients (406 with carotid plaque while 358 without). Results: Among the population aged between 45 and 65, compared to patients without carotid plaque, no significant difference were observed on the genotype or allele frequencies distribution in 9p21 genes including rs10757274, rs7044859, rs4977574 and rs496892 in the patients with carotid plaque. There existed strong linkage disequilibrium not only between rs10757274 and rs4977574 but also between rs7044859 and rs496892 as well. Conclusion: In Chinese Han CI population, there was no significant relevance between the polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in region 9p21 and the susceptibility of carotid plaque. (C) 2016 S. Karger AG, Basel
机构:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
Vet Affairs Med Ctr, Baltimore, MD USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
Cole, John W.
Plourde, Anna
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机构:
Massachusetts Gen Hosp, Stroke Serv, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
机构:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
Vet Affairs Med Ctr, Baltimore, MD USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
Mitchell, Braxton D.
Furie, Karen
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机构:
Massachusetts Gen Hosp, Stroke Serv, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
机构:
Massachusetts Gen Hosp, Stroke Serv, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
Rosand, Jonathan
Kittner, Steve J.
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h-index: 0
机构:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
Vet Affairs Med Ctr, Baltimore, MD USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
机构:
Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Li, Zhiqiang
Zhang, Zhao
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h-index: 0
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Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Zhang, Zhao
He, Zangdong
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h-index: 0
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Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
He, Zangdong
Tang, Wei
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Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Tang, Wei
Li, Tao
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Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Li, Tao
Zeng, Zhen
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h-index: 0
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Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Zeng, Zhen
He, Lin
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
He, Lin
Shi, Yongyong
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机构:
Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
机构:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
Vet Affairs Med Ctr, Baltimore, MD USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
Cole, John W.
Plourde, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Stroke Serv, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
机构:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
Vet Affairs Med Ctr, Baltimore, MD USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
Mitchell, Braxton D.
Furie, Karen
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Stroke Serv, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
机构:
Massachusetts Gen Hosp, Stroke Serv, Boston, MA 02114 USA
Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
Rosand, Jonathan
Kittner, Steve J.
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h-index: 0
机构:
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
Vet Affairs Med Ctr, Baltimore, MD USAUniv Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany
机构:
Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Li, Zhiqiang
Zhang, Zhao
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Zhang, Zhao
He, Zangdong
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
He, Zangdong
Tang, Wei
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Tang, Wei
Li, Tao
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h-index: 0
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Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Li, Tao
Zeng, Zhen
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Zeng, Zhen
He, Lin
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China
Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
He, Lin
Shi, Yongyong
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h-index: 0
机构:
Shanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China
Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R ChinaShanghai Jiao Tong Univ, Affiliated Hosp, Bio X Ctr, Changning Mental Hlth Ctr, Shanghai 200042, Peoples R China