Luteal phase support with GnRH agonist does not eliminate the risk for ovarian hyperstimulation syndrome

被引：8

作者：

Friedler, Shevach ^{[1
,2
]}

Grin, Leonti ^{[1
,2
]}

机构：

[1] Barzilai Univ, Med Ctr, Infertil & IVF Unit, Ashqelon, Israel

[2] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2019年 / 35卷 / 05期

关键词：

GnRH antagonist; GnRH agonist; GnRH agonist trigger; OHSS; luteal support; FINAL OOCYTE MATURATION; HCG; CYCLES; IVF; SUPPLEMENTATION; PROGESTERONE; STIMULATION; OVULATION; TRIGGER;

D O I：

10.1080/09513590.2018.1548591

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aims to report a case of early, severe ovarian hyperstimulation syndrome (OHSS) following GnRH agonist trigger for final oocyte maturation despite luteal support with a GnRH agonist. Contrary to the claim that luteal support using a GnRH agonist eliminates the risk for OHSS in high-risk patients, this report alerts practitioners to the risk of severe OHSS development despite GnRH agonist luteal support in patients receiving GnRH antagonist protocol with GnRH agonist triggering and cautions the practitioners to consider other measures of OHSS prevention.

引用

页码：368 / 369

页数：2

共 19 条

[1] Daily low-dose hCG stimulation during the luteal phase combined with GnRHa triggered IVF cycles without exogenous progesterone: a proof of concept trial [J].

Andersen, Claus Yding ;

Elbaek, Helle Olesen ;

Alsbjerg, Birgit ;

Laursen, Rita Jakubcionyte ;

Povlsen, Betina Boel ;

Thomsen, Lise ;

Humaidan, Peter .

HUMAN REPRODUCTION, 2015, 30 (10) :2387-2395

[2] Intranasal gonadotropin-releasing hormone agonist (GnRHa) for luteal-phase support following GnRHa triggering, a novel approach to avoid ovarian hyperstimulation syndrome in high responders [J].

Bar-Hava, Itai ;

Mizrachi, Yossi ;

Karfunkel-Doron, Daphne ;

Omer, Yeela ;

Sheena, Liron ;

Carmon, Nurit ;

Ben-David, Gila .

FERTILITY AND STERILITY, 2016, 106 (02) :330-333

[3] An OHSS-Free Clinic by segmentation of IVF treatment [J].

Devroey, Paul ;

Polyzos, Nikolaos P. ;

Blockeel, Christophe .

HUMAN REPRODUCTION, 2011, 26 (10) :2593-2597

[4] The effect of luteal phase vaginal estradiol supplementation on the success of in vitro fertilization treatment: a prospective randomized study [J].

Engmann, Lawrence ;

DiLuigi, Andrea ;

Schmidt, David ;

Benadiva, Claudio ;

Maier, Donald ;

Nulsen, John .

FERTILITY AND STERILITY, 2008, 89 (03) :554-561

[5] Rescue of corpus luteum function with peri-ovulatory HCG supplementation in IVF/ICSI GnRH antagonist cycles in which ovulation was triggered with a GnRH agonist: a pilot study [J].

Humaidan, P. ;

Bungum, L. ;

Bungum, M. ;

Andersen, C. Yding .

REPRODUCTIVE BIOMEDICINE ONLINE, 2006, 13 (02) :173-178

[6] Luteal phase supplementation after gonadotropin-releasing hormone agonist trigger in fresh embryo transfer: the American versus European approaches [J].

Humaidan, Peter ;

Engmann, Lawrence ;

Benadiva, Claudio .

FERTILITY AND STERILITY, 2015, 103 (04) :879-885

[7] GnRHa trigger for final oocyte maturation: is HCG trigger history? [J].

Humaidan, Peter ;

Alsbjerg, Birgit .

REPRODUCTIVE BIOMEDICINE ONLINE, 2014, 29 (03) :274-280

[8] 1,500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin-releasing hormone agonist is used for ovulation induction: a prospective, randomized, controlled study [J].

Humaidan, Peter ;

Bredkjaer, Helle Ejdrup ;

Westergaard, Lars Grabou ;

Andersen, Claus Yding .

FERTILITY AND STERILITY, 2010, 93 (03) :847-854

[9] GnRH agonist ovulation trigger and hCG-based, progesterone-free luteal support: a proof of concept study [J].

Kol, Shahar ;

Humaidan, Peter ;

Itskovitz-Eldor, Joseph .

HUMAN REPRODUCTION, 2011, 26 (10) :2874-2877

[10] A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists [J].

Kolibianakis, EM ;

Schultze-Mosgau, A ;

Schroer, A ;

van Steirteghem, A ;

Devroey, P ;

Diedrich, K ;

Griesinger, G .

HUMAN REPRODUCTION, 2005, 20 (10) :2887-2892

← 1 2 →