Emergence of mutant hepatitis B virus during long-term lamivudine therapy in human immunodeficiency virus co-infected-patient

被引:0
作者
Rey, D
Fritsch, S
Schmitt, C
Partisani, M
Kempf-Durepaire, G
Nicolle, M
Krantz, V
De Mautort, E
Stoll-Keller, F
Lang, JM
机构
[1] Hop Univ, Clin Med A, Ctr Informat & Soins Immunodeficience Humaine, F-67091 Strasbourg, France
[2] Fac Med Strasbourg, Inst Virol, Strasbourg, France
来源
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 2000年 / 24卷 / 01期
关键词
hepatitis B virus; lamivudine; human immunodeficiency virus; viral load; resistance;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Seven patients co-infected with hepatitis B virus (HBsAg and HBeAg carriers, quantifiable HBV DNA with the bDNA technic) and human immunodefiency virus received a triple antiretroviral combination therapy, including lamivudine (150mg twice a day). Hepatitis B viral load rapidly became undetectable in 6/7 patients. It remained below the level of detection in 2 subjects, after 20 and 22 months of treatment, with one of them achieving HBeAg/anti-HBe seroconversion. However, in the other 4 individuals, hepatitis B viremia increased again after 8 to 16 months of lamivudine-containing regimen. The last patient was a non-responder. The 4 relapsers developed double mutation Leu(528) for Met(528) and Met(552) for Val(552), on hepatitis B virus polymerase, either concomitant (M8 and M16) with a hepatitis B virus DNA increase, or 2 months earlier (M10 and M12). The high frequency of hepatitis B virus resistance to lamivudine emphasizes the necessity of identifying more effective strategies, such as double combination therapies.
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页码:125 / 127
页数:3
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