Clinical Significance of Monitoring Circulating CD4+CD25+ Regulatory T Cells in Kidney Transplantation during the Early Posttransplant Period

被引：17

作者：

Kim, Su Hyun ^{[3
]}

Oh, Eun-Jee ^{[4
]}

Ghee, Jung Yeon ^{[5
]}

Song, Hyun Kuk ^{[5
]}

Han, Dong He ^{[5
]}

Yoon, Hye Eun ^{[1
]}

Choi, Bum Soon ^{[1
,5
]}

Yoon, Seung Kew ^{[1
,5
]}

Choi, Jong Young ^{[1
,5
]}

Moon, In Sung ^{[2
,5
]}

Kim, Dong Goo ^{[2
,5
]}

Yang, Chul Woo ^{[1
,5
]}

机构：

[1] Catholic Univ Korea, Dept Internal Med, Seoul 137040, South Korea

[2] Catholic Univ Korea, Dept Surg, Seoul 137040, South Korea

[3] Chung Ang Univ, Dept Internal Med, Seoul 156756, South Korea

[4] Catholic Univ Korea, Dept Lab Med, Seoul 137040, South Korea

[5] Catholic Univ Korea, Catholic Transplantat Res Ctr, Seoul 137040, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2009年 / 24卷

关键词：

T-lymphocytes; Regulatory; Graft Rejection; Interleukin-10; Kidney Transplantation; Kidney Failure; Chronic; IMMUNOLOGICAL SELF-TOLERANCE; INTERFERON-GAMMA; ACUTE REJECTION; IN-VITRO; INTERLEUKIN-10; IDENTIFICATION; RAPAMYCIN; LIVER;

D O I：

10.3346/jkms.2009.24.S1.S135

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The CD4(+)CD25(+) T regulatory cells (Tregs) play an important role in immune tolerance in experimental transplantation but the clinical significance of circulating Tregs in the peripheral blood is undetermined. In 50 kidney transplant (KT) recipients, 29 healthy controls and 32 liver transplant (LT) recipients, the frequency of Tregs was measured with flow cytometry before and after transplantation. In the KT recipients, IL-10 secretion was measured with an enzyme-linked immunospot (ELISPOT) assay. The median frequency of circulating Tregs before KT was similar to that in healthy controls but significantly lower than that in LT patients before transplantation. The frequency of Tregs was significantly decreased in patients with subclinical acute rejection compared with those without subclinical acute rejection. Calcineurin inhibitors (CNIs) and anti-CD25 antibody decreased the frequency of Tregs but mTOR inhibitor did not. The frequency of donor-specific IL-10 secreting cells did not correlate with the number of Tregs. The frequency of circulating Tregs in KT recipients is strongly affected by CNIs and anti-CD25 antibody, and a low frequency of Tregs is associated with subclinical acute rejection during the early posttransplant period.

引用

页码：S135 / S142

页数：8

共 28 条

[1] Interleukin-10 but not transforming growth factor-β is essential for generation and suppressor function of regulatory cells induced by intratracheal delivery of alloantigen [J].