Palladium-catalyzed direct Hiyama arylation of quinoxalin-2(1H)-ones with aryl siloxanes in water

被引：18
作者：
Liu, Xinya [1 ]
Liu, Zhenwei [1 ]
Xue, Yingying [1 ]
Li, Jingya [2 ,3 ]
Zou, Dapeng [1 ]
Wu, Yangjie [1 ]
Wu, Yusheng [1 ,2 ,3 ,4 ]
机构：
[1] Zhengzhou Univ, Coll Chem, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Peoples R China
[2] Tetranov Biopharm LLC, Zhengzhou 450052, Peoples R China
[3] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450052, Peoples R China
[4] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 50期
基金：
中国国家自然科学基金;
关键词：
Direct Hiyama arylation; Aryl siloxanes; Quinoxalin-2(1H)-ones; C-H functionalization; C-H ARYLATION; CROSS-COUPLING REACTIONS; BOND ARYLATION; C-3; ARYLATION; METAL; ARYLSILANES; INDOLES; SILICON; ACIDS; ALKENYLATION;
D O I：
10.1016/j.tetlet.2020.152612
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for palladium-catalyzed direct Hiyama coupling of various quinoxalin-2(1H)-ones with aryl siloxanes has been developed. The protocol provides a convenient access to a variety of useful C3-arylated 1-methylquinoxalin-2(1H)-one derivatives in reasonable yields by using low cost water as a solvent and oxygen as an oxidant. (C) 2020 Published by Elsevier Ltd.
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页数：4
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