Understanding virus-host dynamics following EIAV infection in SCID horses

被引：6

作者：

Ciupe, Stanca M. ^{[1
]}

Schwartz, Elissa J. ^{[2
,3
]}

机构：

[1] Virginia Tech, Dept Math, Blacksburg, VA 24060 USA

[2] Washington State Univ, Sch Biol Sci, Pullman, WA 99164 USA

[3] Washington State Univ, Dept Math, Pullman, WA 99164 USA

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2014年 / 343卷

基金：

美国国家科学基金会;

关键词：

EIAV; SCID; Antibody; Mathematical models; ANEMIA VIRUS; IMMUNE-RESPONSES; VIRAL REPLICATION; HIV; IMMUNODEFICIENCY; IMMUNOGLOBULIN; LYMPHOCYTES; EVOLUTION; COMPLEX; PLASMA;

D O I：

10.1016/j.jtbi.2013.11.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We develop a mathematical model for the interaction between two competing equine infectious anemia virus strains and neutralizing antibodies. We predict that elimination of one or both virus strains depends on the initial antibody levels, the strength of antibody mediated neutralization, and the persistence of antibody over time. We further show that the ability of a subdominant, neutralization resistant virus to dominate the infection transiently or permanently is dependent on the antibody-mediated neutralization effect. Finally, we determine conditions for persistence of both virus strains. We fit our models to virus titers from horses (foals) with severe combined immunodeficiency to estimate virus-host parameters and to validate analytical results. (C) 2013 Elsevier Ltd. All rights reserved.

引用

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页码：1 / 8

页数：8

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