Role of chemokines in proteinuric kidney disorders

被引：15

作者：

Antonio Moreno, Juan ^{[1
]}

Moreno, Sara ^{[2
]}

Rubio-Navarro, Alfonso ^{[1
]}

Gomez-Guerrero, Carmen ^{[1
,4
]}

Ortiz, Alberto ^{[1
,3
]}

Egido, Jesus ^{[1
,3
,4
]}

机构：

[1] Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Dept Nephrol, Madrid, Spain

[2] INIA, Dept Biotechnol, Madrid, Spain

[3] FRIAT, IRSIN, Madrid, Spain

[4] Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain

来源：

EXPERT REVIEWS IN MOLECULAR MEDICINE | 2014年 / 16卷

关键词：

MONOCYTE CHEMOATTRACTANT PROTEIN-1; PROXIMAL TUBULAR CELLS; NF-KAPPA-B; TYPE-2; DIABETIC-NEPHROPATHY; RENAL-DISEASE; RECEPTOR ANTAGONIST; LUPUS NEPHRITIS; UP-REGULATION; T-CELLS; INTERSTITIAL INFLAMMATION;

D O I：

10.1017/erm.2014.3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent progress in cellular and molecular understanding of the role of chemokines in the pathogenesis of proteinuria-induced renal injury, as well as their clinical implications and therapeutic potential.

引用

页数：21

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