Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity by dopachrome analogs

被引：0
作者：
Zhang, XN [1 ]
Bucala, R [1 ]
机构：
[1] Picower Inst Med Res, Manhasset, NY 11030 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 22期
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A macrophage migration inhibitory factor (MIF) dopachrome tautomerization assay was employed for identification of MIF inhibitors. One group of dopachrome analogs was identified which inhibits MIF tautomerase activity. In particular, the analogs with a leaving group at beta position displayed activity at a concentration of tenfold less than that of the MIF-substrate. These findings could lead to a better understanding of MIF biological activities and the development of agents for the treatment of MIF related diseases. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：3193 / 3198
页数：6
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