Role of P glycoprotein in absorption of novel antimalarial drugs

被引：36
作者：
Crowe, Andrew
Ilett, Kenneth F.
Karunajeewa, Harin A.
Batty, Kevin T.
Davis, Timothy M. E.
机构：
[1] Curtin Univ Technol, Sch Pharm, Perth, WA 6845, Australia
[2] Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 10期
关键词：
D O I：
10.1128/AAC.00708-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 mu M) and low for naphthoquine (5 mu M). With 20 mu M naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.
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收藏
页码：3504 / 3506
页数：3
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