Reduction in False-Positive Aspergillus Serum Galactomannan Enzyme Immunoassay Results Associated with Use of Piperacillin-Tazobactam in the United States

被引：46

作者：

Vergidis, Paschalis ^{[1
]}

Razonable, Raymund R. ^{[1
]}

Wheat, L. Joseph ^{[2
]}

Estes, Lynn ^{[1
]}

Caliendo, Angela M. ^{[3
]}

Baden, Lindsey R. ^{[4
]}

Wingard, John R. ^{[5
]}

Baddley, John ^{[6
]}

Assi, Maha ^{[7
]}

Norris, Steven ^{[8
]}

Chandrasekar, Pranatharthi ^{[9
]}

Shields, Ryan ^{[10
]}

Nguyen, Hong ^{[10
]}

Freifeld, Alison ^{[11
]}

Kohler, Richard ^{[12
]}

Kleiman, Martin ^{[13
]}

Walsh, Thomas J. ^{[14
]}

Hageo, Chadi A. ^{[15
]}

机构：

[1] Mayo Clin, Coll Med, Rochester, MN 55905 USA

[2] MiraVista Diagnost & Mirabella Technol, Indianapolis, IN USA

[3] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

[4] Brigham & Womens Hosp, Boston, MA 02115 USA

[5] Univ Florida, Coll Med, Gainesville, FL USA

[6] Univ Alabama Birmingham, Birmingham, AL USA

[7] Univ Kansas, Sch Med, Wichita, KS 67214 USA

[8] Community Infect Dis, Indianapolis, IN USA

[9] Wayne State Univ, Detroit, MI USA

[10] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA

[11] Univ Nebraska, Med Ctr, Omaha, NE USA

[12] Indiana Univ, Wishard Mem Hosp, Indianapolis, IN 46202 USA

[13] Indiana Univ, Riley Mem Hosp, Indianapolis, IN 46204 USA

[14] Weill Cornell Med Ctr, New York, NY USA

[15] Indiana Univ, Thorac Transplantat Program, Indianapolis, IN 46204 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2014年 / 52卷 / 06期

关键词：

HEMATOLOGICAL DISORDERS; ANTIGENEMIA; DIAGNOSIS; PLATELIA;

D O I：

10.1128/JCM.00285-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Piperacillin-tazobactam (PTZ) is known to cause false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA), due to contamination with galactomannan (GM). We tested 32 lots of PTZ and 27 serum specimens from patients receiving PTZ. GM was not detected in the lots of PTZ; one serum specimen (3.7%) was positive. PTZ formulations commonly used in the United States today appear to be a rare cause for false-positive GM results.

引用

页码：2199 / 2201

页数：3

共 11 条

[1] Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies [J].