Biologically Active Cannabinoids from High-Potency Cannabis sativa

被引：139

作者：

Radwan, Mohamed M. ^{[1
]}

ElSohly, Mahmoud A. ^{[1
,2
]}

Slade, Desmond ^{[1
]}

Ahmed, Safwat A. ^{[1
]}

Khan, Ikhas A. ^{[1
,3
]}

Ross, Samir A. ^{[1
,3
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmaceut, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 05期

关键词：

CONSTITUENTS; CANNABICHROMENE; DERIVATIVES; VARIETY; ANALOGS;

D O I：

10.1021/np900067k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new cannabinoids (1-9) were isolated from a high-potency variety of Cannabis sativa. Their structures were identified as (+/-)-4-acetoxycannabichromene (1), (+/-)-3 ''-hydroxy-Delta((4 '',5 ''))-cannabichromene (2), (-)-7-hydroxycannabichromane (3), (-)-7R-cannabicoumarononic acid A (4), 5-acetyl-4-hydroxycannabigerol (5), 4-acetoxy-2-geranyl-5-hydroxy-3-n-pentylphenol (6), 8-hydroxycannabinol (7), 8-hydroxycannabinolic acid A (8), and 2-geranyl-5-hydroxy-3-n-pentyl-1,4-benzoquinone (9) through 1D and 2D NMR spectroscopy, GC-MS, and HRESIMS. The known sterol beta-sitosterol-3-O-beta-D-glucopyranosyl-6'-acetate was isolated for the first time from cannabis. Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity.

引用

页码：906 / 911

页数：6

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