TRACING THE ORIGIN AND DYNAMICS OF THE HIV-1 EPIDEMIC IN SERBIA

被引：1

作者：

Siljic, Marina ^{[1
]}

Salemovic, Dubravka ^{[2
]}

Jevtovic, Dj. ^{[2
]}

Pesic-Pavlovic, Ivana ^{[2
]}

Zerjav, Sonja ^{[2
]}

Nikolic, Valentina ^{[1
]}

Ranin, J. ^{[2
]}

Stanojevic, Maja ^{[1
]}

机构：

[1] Univ Belgrade, Fac Med, Inst Microbiol & Immunol, Belgrade 11000, Serbia

[2] Ctr HIV AIDS, Inst Infect & Trop Dis CCS, Belgrade 11000, Serbia

来源：

ARCHIVES OF BIOLOGICAL SCIENCES | 2014年 / 66卷 / 02期

关键词：

Serbian epidemic; subtype distribution; HIV-1; transmission; Bayesian coalescent analyses; SUBTYPE-B; EVOLUTIONARY HISTORY; POPULATION HISTORY; COMMON ANCESTOR; RECONSTRUCTION; TRANSMISSION; STRAINS; EUROPE;

D O I：

10.2298/ABS1402507S

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since the first report of HIV infection in Serbia in 1985, the HIV-1 epidemic was very dynamic, changing the pattern in subtype distribution and prevailing transmission routes. To better understand the origin and epidemiological dynamics of HIV-1, we analyzed 266 (pol) sequences from Serbian patients diagnosed over a period of 14 years. Subtype distribution in Serbia is still marked by a prevailing subtype B genetic form. The transmission pattern, however, has changed from being intravenous drug user (IVDU) - driven to predominantly sexual transmission. The estimated time of initial founder strain introduction of sequences from Serbian IVDUs and MSM (men who have sex with men) is similar and dates back to the early 1980s, while introduction of subtype C occurred much more recently.

引用

页码：507 / 515

页数：9

共 33 条

[1] Timing of the HIV-1 subtype C epidemic in Ethiopia based on early virus strains and subsequent virus diversification
Abebe, A
Lukashov, VV
Pollakis, G
Kliphuis, A
Fontanet, AL
Goudsmit, J
de Wit, TFR
[J]. AIDS, 2001, 15 (12) : 1555 - 1561
[2] HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics
Abecasis, Ana B.
Wensing, Annemarie M. J.
Paraskevis, Dimitris
Vercauteren, Jurgen
Theys, Kristof
de Vijver, David A. M. C. Van
Albert, Jan
Asjo, Birgitta
Balotta, Claudia
Beshkov, Danail
Camacho, Ricardo J.
Clotet, Bonaventura
De Gascun, Cillian
Griskevicius, Algis
Grossman, Zehava
Hamouda, Osamah
Horban, Andrzej
Kolupajeva, Tatjana
Korn, Klaus
Kostrikis, Leon G.
Kuecherer, Claudia
Liitsola, Kirsi
Linka, Marek
Nielsen, Claus
Otelea, Dan
Paredes, Roger
Poljak, Mario
Puchhammer-Stoeckl, Elisabeth
Schmit, Jean-Claude
Sonnerborg, Anders
Stanekova, Danika
Stanojevic, Maja
Struck, Daniel
Boucher, Charles A. B.
Vandamme, Anne-Mieke
[J]. RETROVIROLOGY, 2013, 10
[3] Quantifying Differences in the Tempo of Human Immunodeficiency Virus Type 1 Subtype Evolution
Abecasis, Ana B.
Vandamme, Anne-Mieke
Lemey, Philippe
[J]. JOURNAL OF VIROLOGY, 2009, 83 (24) : 12917 - 12924
[4] Evolutionary history of HIV-1 subtype B and F infections in Brazil
Bello, G
Guimares, ML
Morgado, MG
[J]. AIDS, 2006, 20 (05) : 763 - 768
[5] Preface
Deng, Xiaotie
Ye, Yinyu
[J]. ALGORITHMICA, 2008, 52 (01) : 1 - 2
[6] Drummond AJ, 2002, GENETICS, V161, P1307
[7] Spreading of HIV-1 subtype G and envB/gagG recombinant strains among injecting drug users in Lisbon, Portugal
Esteves, A
Parreira, R
Piedade, J
Venenno, T
Franco, M
de Sousa, JG
Patrício, L
Brum, P
Costa, A
Canas-Ferreira, WF
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2003, 19 (06) : 511 - 517
[8] The emergence of HIV/AIDS in the Americas and beyond
Gilbert, M. Thomas P.
Rambaut, Andrew
Wlasiuk, Gabriela
Spira, Thomas J.
Pitchenik, Arthur E.
Worobey, Michael
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) : 18566 - 18570
[9] Han X, 2013, J ACQUIR IMMUNE DEFI
[10] The origin and diversity of the HIV-1 pandemic
Hemelaar, Joris
[J]. TRENDS IN MOLECULAR MEDICINE, 2012, 18 (03) : 182 - 192

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