RefSeq: an update on mammalian reference sequences

被引：720

作者：

Pruitt, Kim D. ^{[1
]}

Brown, Garth R. ^{[1
]}

Hiatt, Susan M. ^{[1
]}

Thibaud-Nissen, Francoise ^{[1
]}

Astashyn, Alexander ^{[1
]}

Ermolaeva, Olga ^{[1
]}

Farrell, Catherine M. ^{[1
]}

Hart, Jennifer ^{[1
]}

Landrum, Melissa J. ^{[1
]}

McGarvey, Kelly M. ^{[1
]}

Murphy, Michael R. ^{[1
]}

O'Leary, Nuala A. ^{[1
]}

Pujar, Shashikant ^{[1
]}

Rajput, Bhanu ^{[1
]}

Rangwala, Sanjida H. ^{[1
]}

Riddick, Lillian D. ^{[1
]}

Shkeda, Andrei ^{[1
]}

Sun, Hanzhen ^{[1
]}

Tamez, Pamela ^{[1
]}

Tully, Raymond E. ^{[1
]}

Wallin, Craig ^{[1
]}

Webb, David ^{[1
]}

Weber, Janet ^{[1
]}

Wu, Wendy ^{[1
]}

DiCuccio, Michael ^{[1
]}

Kitts, Paul ^{[1
]}

Maglott, Donna R. ^{[1
]}

Murphy, Terence D. ^{[1
]}

Ostell, James M. ^{[1
]}

机构：

[1] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

基金：

美国国家卫生研究院;

关键词：

DATABASE; RESOURCES;

D O I：

10.1093/nar/gkt1114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The National Center for Biotechnology Information (NCBI) Reference Sequence (RefSeq) database is a collection of annotated genomic, transcript and protein sequence records derived from data in public sequence archives and from computation, curation and collaboration (http://www.ncbi.nlm.nih.gov/refseq/). We report here on growth of the mammalian and human subsets, changes to NCBI's eukaryotic annotation pipeline and modifications affecting transcript and protein records. Recent changes to NCBI's eukaryotic genome annotation pipeline provide higher throughput, and the addition of RNAseq data to the pipeline results in a significant expansion of the number of transcripts and novel exons annotated on mammalian RefSeq genomes. Recent annotation changes include reporting supporting evidence for transcript records, modification of exon feature annotation and the addition of a structured report of gene and sequence attributes of biological interest. We also describe a revised protein annotation policy for alternatively spliced transcripts with more divergent predicted proteins and we summarize the current status of the RefSeqGene project.

引用

页码：D756 / D763

页数：8

共 24 条

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