The Central Nervous System as a Sanctuary Site in ALK-Positive Non-Small-Cell Lung Cancer

被引：110

作者：

Gainor, Justin F. ^{[1
]}

Ou, Sai-Hong Ignatius ^{[3
]}

Logan, Jennifer ^{[1
]}

Borges, Lawrence F. ^{[2
]}

Shaw, Alice T. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Dept Med, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Ctr Canc, Dept Neurosurg, Boston, MA 02114 USA

[3] Univ Calif Irvine, Dept Med, Orange, CA 92668 USA

来源：

JOURNAL OF THORACIC ONCOLOGY | 2013年 / 8卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Anaplastic lymphoma kinase; ALK; Intramedullary spinal cord metastasis; Leptomeningeal carcinomatosis; BRAIN METASTASES; CRIZOTINIB; ADENOCARCINOMA;

D O I：

10.1097/JTO.0000000000000029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anaplastic lymphoma kinase (ALK) gene rearrangements define a distinct molecular subset of non-small-cell lung cancer that is highly responsive to treatment with the ALK inhibitor crizotinib. Recently, it has been recognized that the brain is a frequent site of relapse among ALK-positive patients treated with crizotinib. In this report, we expand on these observations and present a series of ALK-positive patients with two distinct forms of metastatic, central nervous system involvement: intramedullary spinal cord metastasis and leptomeningeal carcinomatosis.

引用

页码：1570 / 1573

页数：4

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