The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends

被引：65

作者：

Agarwal, Aniruddha ^{[1
]}

Agrawal, Rupesh ^{[2
,3
,4
,5
]}

Gunasekaran, Dinesh Visva ^{[2
,3
,4
]}

Raje, Dhananjay ^{[6
]}

Gupta, Bhaskar ^{[7
]}

Aggarwal, Kanika ^{[1
]}

Murthy, Somasheila L. ^{[8
]}

Westcott, Mark ^{[3
]}

Chee, Soon Phaik ^{[4
,5
,9
,10
]}

McCluskey, Peter ^{[11
]}

Ling, Ho Su ^{[2
]}

Teoh, Stephen ^{[2
]}

Cimino, Luca ^{[12
]}

Biswas, Jyotirmay ^{[13
]}

Narain, Shishir ^{[14
]}

Agarwal, Manisha ^{[15
]}

Mahendradas, Padmamalini ^{[16
]}

Khairallah, Moncef ^{[17
]}

Jones, Nicholas ^{[18
]}

Tugal-Tutkun, Ilknur ^{[19
]}

Babu, Kalpana ^{[20
]}

Basu, Soumayava ^{[21
]}

Carreno, Ester ^{[22
]}

Lee, Richard ^{[22
]}

Al-Dhibi, Hassan ^{[23
]}

Bodaghi, Bahram ^{[24
]}

Invernizzi, Alessandro ^{[25
]}

Goldstein, Debra A. ^{[26
]}

Herbort, Carl P. ^{[27
,28
]}

Barisani-Asenbauer, Talin ^{[29
]}

Gonzalez-Lopez, Julio J. ^{[30
]}

Androudi, Sofia ^{[31
]}

Bansal, Reema ^{[1
]}

Moharana, Bruttendu ^{[1
]}

Mahajan, Sarakshi ^{[1
]}

Esposti, Simona ^{[3
]}

Tasiopoulou, Anastasia ^{[3
]}

Nadarajah, Sengal ^{[3
]}

Agarwal, Mamta ^{[13
]}

Abraham, Sharanya ^{[13
]}

Vala, Ruchi ^{[16
]}

Singh, Ramandeep ^{[1
]}

Sharma, Aman ^{[32
]}

Sharma, Kusum ^{[33
]}

Zierhut, Manfred ^{[34
]}

Kon, Onn Min ^{[35
]}

Cunningham, Emmett ^{[36
]}

Quan Dong Nguyen ^{[37
]}

Pavesio, Carlos ^{[3
]}

Gupta, Vishali ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Adv Eye Ctr, Chandigarh, India

[2] Tan Tock Seng Hosp, Inst Eye, Natl Healthcare Grp, Singapore, Singapore

[3] NHS Fdn Trust, Moorfields Eye Hosp, London, England

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore

[5] Singapore Eye Res Inst, Singapore, Singapore

[6] Royal Statistician Soc, CSTAT, London, England

[7] NHS Fdn Trust, Royal Berkshire Hosp, Reading, Berks, England

[8] LV Prasad Eye Inst, Tej Kohli Cornea Inst, Kallam Anji Reddy Campus, Hyderabad, Telangana, India

[9] Singapore Natl Eye Ctr, Singapore, Singapore

[10] Duke NUS Med Sch, Singapore, Singapore

[11] Univ Sydney, Cent Clin Sch, Save Sight Inst, Dept Clin Ophthalmol & Eye Hlth, Sydney, NSW, Australia

[12] Arcispedale IRCCS Arcispedale Santa Maria Nuova, Dept Ophthalmol, Ocular Immunol Unit, Reggio Emilia, Italy

[13] Sankara Nethralaya, Chennai, Tamil Nadu, India

[14] Shroff Eye Ctr, New Delhi, India

[15] Dr Shroffs Charity Eye Hosp Daryaganj, New Delhi, India

[16] Narayana Nethralaya, Bangalore, Karnataka, India

[17] Univ Monastir, Fac Med, Fattouma Bourguiba Univ Hosp, Dept Ophthalmol, Monastir, Tunisia

[18] Univ Manchester, Manchester, Lancs, England

[19] Istanbul Univ, Dept Ophthalmol, Istanbul Fac Med, Istanbul, Turkey

[20] Vittala Int Inst Ophthalmol, Prabha Eye Clin & Res Ctr, Dept Ophthalmol, Bangalore, Karnataka, India

[21] LV Prasad Eye Inst, Bhubaneswar, Odisha, India

[22] Bristol Eye Hosp, Bristol, Avon, England

[23] King Khalid Eye Specialist Hosp, Riyadh, Saudi Arabia

[24] Univ Paris 06, DHU SightRestore, Paris, France

[25] Univ Milan, Luigi Sacco Hosp, Dept Biomed & Clin Sci L Sacco, Eye Clin, Milan, Italy

[26] Northwestern Univ, Dept Ophthalmol, Feinberg Sch Med, Chicago, IL 60611 USA

[27] Ctr Ophthalm Specialised Care, Lausanne, Switzerland

[28] Univ Lausanne, Lausanne, Switzerland

[29] Med Univ Vienna, Ctr Pathophysiol Immunol & Infectiol, Laura Bassi Ctr Expertise Ocuvac, Vienna, Austria

[30] Univ Alcala, Ramon Y Cajal Univ Hosp, IRYCIS, Alcala De Henares, Spain

[31] Univ Thessaly, Dept Ophthalmol, Volos, Greece

[32] PGIMER, Dept Rheumatol, Chandigarh, India

[33] PGIMER, Dept Microbiol, Chandigarh, India

[34] Univ Tubingen, Ctr Ophthalmol, Tubingen, Germany

[35] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Chest & Allergy Clin, London, England

[36] Univ Calif San Francisco, Francis I Proctor Fdn Res Ophthalmol, San Francisco, CA 94143 USA

[37] Stanford Univ, Byers Eye Inst, Palo Alto, CA 94304 USA

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2019年 / 27卷 / 03期

关键词：

Anti-tubercular therapy; choroidal tuberculoma; choroiditis; polymerase chain reaction; tuberculosis; INTRAOCULAR TUBERCULOSIS; PCR; CHOROIDITIS;

D O I：

10.1080/09273948.2017.1406529

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions: Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.

引用

页码：465 / 473

页数：9

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