Cell types to order: temporal specification of CNS stem cells

被引：175

作者：

Okano, Hideyuki ^{[1
]}

Temple, Sally ^{[2
]}

机构：

[1] Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, Tokyo 1120012, Japan

[2] New York Neural Stem Cell Inst, Rensselaer, NY 12144 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2009年 / 19卷 / 02期

关键词：

CENTRAL-NERVOUS-SYSTEM; TRANSCRIPTION FACTORS; DNA METHYLATION; GENE-EXPRESSION; COUP-TFI; DIFFERENTIATION; DROSOPHILA; NEURONS; FATE; NEUROGENESIS;

D O I：

10.1016/j.conb.2009.04.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spatial and temporal specification of neural progenitor cells is integral to their production of a wide variety of central nervous system (CNS) cells. For a given region, cells arise on a precise and predictable temporal schedule, with sub-types of neurons appearing in a defined order, followed by glial cell generation. Single cell studies have shown that the timing of cell generation can be encoded within individual early progenitor cells as a cell-intrinsic program. Environmental cues are important modulators of this program, allowing it to unfold and coordinating the process within the embryo. Here we review recent findings on the molecular mechanisms of epigenetic and transcription factor regulation, which are involved in temporal specification of CNS stem cells.

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收藏

页码：112 / 119

页数：8

相关论文

共 51 条

[1] Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development [J].

Anthony, Todd E. ;

Heintz, Nathaniel .

NEURAL DEVELOPMENT, 2008, 3 (1)

[2] Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum [J].

Arlotta, Paola ;

Molyneaux, Bradley J. ;

Jabaudon, Denis ;

Yoshida, Yutaka ;

Macklis, Jeffrey D. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (03) :622-632

[3] Evidence that embryonic the onset of cortical neurons regulate gliogenesis via cardiotrophin-1 [J].

Barnabé-Heider, F ;

Wasylnka, JA ;

Fernandes, KJL ;

Porsche, C ;

Sendtner, M ;

Kaplan, DR ;

Miller, FD .

NEURON, 2005, 48 (02) :253-265

[4] Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway [J].

Bonni, A ;

Sun, Y ;

NadalVicens, M ;

Bhatt, A ;

Frank, DA ;

Rozovsky, I ;

Stahl, N ;

Yancopoulos, GD ;

Greenberg, ME .

SCIENCE, 1997, 278 (5337) :477-483

[5] Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex [J].

Britanova, Olga ;

de Juan Romero, Camino ;

Cheung, Amanda ;

Kwan, Kenneth Y. ;

Schwark, Manuela ;

Gyorgy, Andrea ;

Vogel, Tanja ;

Akopov, Sergey ;

Mitkovski, Mico ;

Agoston, Denes ;

Sestan, Nenad ;

Molnar, Zoltan ;

Tarabykin, Victor .

NEURON, 2008, 57 (03) :378-392

[6] Programmed transformations in neuroblast gene expression during Drosophila CNS lineage development [J].

Brody, T ;

Odenwald, WF .

DEVELOPMENTAL BIOLOGY, 2000, 226 (01) :34-44

[7] Forever young: Death-defying neuroblasts [J].

Chell, James M. ;

Brand, Andrea H. .

CELL, 2008, 133 (05) :769-771

[8] The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex [J].

Chen, Bin ;

Wang, Song S. ;

Hattox, Alexis M. ;

Rayburn, Helen ;

Nelson, Sacha B. ;

McConnell, Susan K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (32) :11382-11387

[9] The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord [J].

Deneen, Benjamin ;

Ho, Ritchie ;

Lukaszewicz, Agnes ;

Hochstim, Christian J. ;

Gronostajski, Richard M. ;

Anderson, David J. .

NEURON, 2006, 52 (06) :953-968

[10] Ikaros Confers Early Temporal Competence to Mouse Retinal Progenitor Cells [J].

Elliott, Jimmy ;

Jolicoeur, Christine ;

Ramamurthy, Vasanth ;

Cayouette, Michel .

NEURON, 2008, 60 (01) :26-39

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