Early-life nutritional programming of longevity

被引:37
作者
Vaiserman, A. M. [1 ]
机构
[1] NAMS Ukraine, DF Chebotarev State Inst Gerontol, Kiev, Ukraine
关键词
aging-associated disease; developmental nutritional programming; epigenetic regulation; longevity; LOW-PROTEIN-DIET; GROWTH-FACTOR-I; CATCH-UP GROWTH; POOR MATERNAL NUTRITION; CORONARY-HEART-DISEASE; 1959-1961 GREAT LEAP; BREAST-CANCER RISK; LOW-BIRTH-WEIGHT; DEVELOPMENTAL ORIGINS; PRENATAL EXPOSURE;
D O I
10.1017/S2040174414000294
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Available data from both experimental and epidemiological studies suggest that inadequate diet in early life can permanently change the structure and function of specific organs or homoeostatic pathways, thereby 'programming' the individual's health status and longevity. Sufficient evidence has accumulated showing significant impact of epigenetic regulation mechanisms in nutritional programming phenomenon. The essential role of early-life diet in the development of aging-related chronic diseases is well established and described in many scientific publications. However, the programming effects on lifespan have not been extensively reviewed systematically. The aim of the review is to provide a summary of research findings and theoretical explanations that indicate that longevity can be influenced by early nutrition.
引用
收藏
页码:325 / 338
页数:14
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