Heterogenic colonization patterns by Leptospira interrogans in Rattus norvegicus from urban slums

被引：12

作者：

Nunes Santos, Ana Amelia ^{[1
]}

Figueira, Claudio Pereira ^{[2
]}

dos Reis, Mitermayer Galvao ^{[1
]}

Costa, Federico ^{[3
,4
,5
]}

Ristow, Paula ^{[1
,6
]}

机构：

[1] Fundacao Oswaldo Cruz, Lab Patol & Biol Mol, Salvador, BA, Brazil

[2] Fundacao Oswaldo Cruz, Plataforma Microscopia Eletron, Salvador, BA, Brazil

[3] Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil

[4] Fundacao Oswaldo Cruz, Nucleo Epidemiol & Bioestat, Salvador, BA, Brazil

[5] Yale Univ, Sch Publ Hlth, Div Epidemiol Microbial Dis, New Haven, CT 06520 USA

[6] Univ Fed Bahia, Inst Biol, Lab Bacteriol & Saude, Salvador, BA, Brazil

来源：

BRAZILIAN JOURNAL OF MICROBIOLOGY | 2015年 / 46卷 / 04期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

Leptospira interrogans; renal colonization; natural reservoirs; Rattus norvegicus; ENVIRONMENT;

D O I：

10.1590/S1517-838246420140873

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the renal colonization by Leptospira interrogans in Rattus norvegicus (rats), as it is the major natural reservoir of urban leptospirosis. We caught 72 R. norvegicus, out of which 32 were found to be positive for L. interrogans by immunofluorescence assay. From these rats, we selected 17 and divided them into six groups based on the mass-age/sex. We performed the immunohistochemistry test against L. interrogans in the kidney sections of the rats and systematically counted the colonized tubules (CTs) in 20 fields. The proportion of positive fields varied from 5% to 95%. The number of CTs in 20 fields varied from 0.5 to 85.5. These differences were not related to age or sex of the animals. The characterization of leptospiral colonization patterns in the natural reservoirs is important to better understand the host-pathogen interactions in leptospirosis.

引用

页码：1161 / 1164

页数：4

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